Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice

Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect’s chitin synthesis and by consequences, making insect more susceptible to pathogens and malformat...

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Bibliographic Details
Published in:Environmental science and pollution research international 2019-02, Vol.26 (4), p.3723-3730
Main Authors: Timoumi, Rim, Amara, Ines, Neffati, Fadwa, Najjar, Mohamed Fadhel, El Golli-Bennour, Emna, Bacha, Hassen, Abid-Essefi, Salwa
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Aquatic Pollution
Aspartate transaminase
Atmospheric Protection/Air Quality Control/Air Pollution
Bilirubin
Carbonyl compounds
Carbonyls
Catalase
Chitin
Creatinine
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Enzymatic activity
Glutathione peroxidase
Growth regulators
Insecticides
Insects
Kidneys
Liver
Malondialdehyde
Markers
Mice
Oxidation
Oxidative stress
Parameters
Peroxidase
Perturbation
Proteins
Research Article
Superoxide dismutase
Toxicity
Transaminase
Triflumuron
Urea
Uric acid
Waste Water Technology
Water Management
Water Pollution Control
γ-Glutamyltransferase
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Summary:Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect’s chitin synthesis and by consequences, making insect more susceptible to pathogens and malformations. TFM effects have been reported in mammalians and crops. However, studies that reveal its toxicity mechanisms are limited. In this line, the current study aimed to determine the implication of oxidative stress in the toxicity induced by TFM and particularly in the perturbation of biochemical parameters in male Balb/C mice. Male Balb/C mice were divided into three groups receiving TFM at doses of 250, 350, and 500 mg/kg bw respectively. The occurrence of oxidative stress in both kidney and liver tissues was monitored by measuring of oxidative stress markers. TFM caused an increase as protein carbonyls generation, malondialdehyde induction (MDA) and catalase (CAT), superoxide dismutase (SOD), glutathion peroxidase (Gpx), as well as glutathion S transferase (GST) activities. In the same conditions, we have evaluated the effect of TFM treatment on biochemical parameters. In response to the three TFM doses, we showed significant dose dependent inductions in all tested oxidative stress markers. However, TFM caused an increase in the liver enzyme activities as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), g-glutamyltranspeptidase (GTT), and total bilirubin (BILT) in a dose-dependent manner. Equally, renal markers as urea, uric acid, albumin, and creatinine were increased in the same manner. We can conclude that oxidative damage seems to be a key determinant of TFM-induced toxicity in both liver and kidney of male Balb/C mice. Moreover, the oxidative stress is more pronounced in the liver than in the kidney. Thus, TFM may be considered as a hepatotoxic insecticide.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-018-3908-8