Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

Background This study investigated the influence of single nucleotide polymorphisms (SNP) in RAD51 and XRCC3 on susceptibility to oral and oropharyngeal squamous cell carcinomas (SCC) and determined their clinicopathological significance. Subjects and Methods SNPs rs1801320 and rs1801321 in RAD51 an...

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Bibliographic Details
Published in:Oral diseases 2019-01, Vol.25 (1), p.54-63
Main Authors: Santos, Edilmar de Moura, Santos, Hellen Bandeira de Pontes, de Matos, Felipe Rodrigues, Machado, Renato Assis, Coletta, Ricardo D., Galvão, Hébel Cavalcanti, Freitas, Roseana de Almeida
Format: Article
Language:English
Subjects:
Alcohol
Alcohol Drinking - adverse effects
Alleles
Cancer
Carcinogens
Carcinoma - genetics
Carcinoma, Squamous Cell - genetics
Case-Control Studies
DNA repair
DNA-Binding Proteins - genetics
Environmental factors
Genetic Predisposition to Disease
Genotype
Humans
Oral cancer
Oral carcinoma
oral squamous cell carcinoma
Oropharyngeal Neoplasms - genetics
oropharyngeal squamous cell carcinoma
Oropharyngolaryngeal carcinoma
Polymorphism, Single Nucleotide
RAD51
Rad51 Recombinase - genetics
Regression analysis
Risk Factors
Single-nucleotide polymorphism
Smoking
Smoking - adverse effects
Squamous cell carcinoma
Throat cancer
Tobacco
XRCC3
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Summary:Background This study investigated the influence of single nucleotide polymorphisms (SNP) in RAD51 and XRCC3 on susceptibility to oral and oropharyngeal squamous cell carcinomas (SCC) and determined their clinicopathological significance. Subjects and Methods SNPs rs1801320 and rs1801321 in RAD51 and rs861539 in XRCC3 were genotyped in 81 patients presenting oral SCC, 45 presenting oropharyngeal SCC, and 130 healthy controls, using TaqMan allelic discrimination assays. Multiple logistic regression models were used to explore the association between SNPs and cancer development, as well as gene–gene (GxG) interaction and gene–environmental factor (GxE) interaction. Clinicopathological associations were verified through the chi‐square test, and univariate and multivariate methods were applied for survival analyses. Results Although allelic and genotypic models and the GxG interaction analysis were nonsignificant, the GxE analysis revealed synergistic effects of the risk alleles of rs1801320, rs1801321, and rs861539 with smoking and alcohol consumption on susceptibility to oral and oropharyngeal SCC. Furthermore, oropharyngeal SCC patients carrying the XRCC3 rs861539 GT/TT genotype (T risk allele) presented a shorter overall survival than GG genotype carriers. Conclusion Combined effects of RAD51 (rs1801320 and rs1801321) and XRCC3 (rs861539) SNPs with environmental carcinogens (tobacco and alcohol) are associated with oral and oropharyngeal SCC development.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12943