Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-L-tyrosine

The whole-body distribution of O-(2-[(18)F]fluoroethyl)- l-tyrosine (FET) was studied in seven patients with brain tumours by positron emission tomography (PET). Based on the IMEDOSE and MIRDOSE procedures, radiation absorbed doses were estimated from whole-body PET scans acquired approximately 70 a...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2003-04, Vol.30 (4), p.519-524
Main Authors: PAULEIT, Dirk, FLOETH, Frank, HERZOG, Hans, HAMACHER, Kurt, TELLMANN, Lutz, MÜLLER, Hans-W, COENEN, Heinz H, LANGEN, Karl-J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - metabolism
Female
Fluorine Radioisotopes - blood
Fluorine Radioisotopes - pharmacokinetics
Fluorine Radioisotopes - urine
Humans
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Organ Specificity
Radiation Dosage
Radiometry - methods
Radionuclide Imaging
Radiopharmaceuticals - blood
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - urine
Tissue Distribution
Tyrosine - analogs & derivatives
Tyrosine - blood
Tyrosine - pharmacokinetics
Tyrosine - urine
Whole-Body Counting
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Summary:The whole-body distribution of O-(2-[(18)F]fluoroethyl)- l-tyrosine (FET) was studied in seven patients with brain tumours by positron emission tomography (PET). Based on the IMEDOSE and MIRDOSE procedures, radiation absorbed doses were estimated from whole-body PET scans acquired approximately 70 and 200 min after i.v. injection of 400 MBq FET. After injection of FET, the peak of radioactivity in the blood was observed after 1.5 min, and a plateau of nearly constant radioactivity was reached at 20 min. The whole-body distribution of FET showed the highest activities in the urinary tract. All other organs exhibited only moderate FET uptake (SUV
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-003-1118-0