MAGNETIC RESONANCE IMAGING-GUIDED CONTOURING IN STEREOTACTIC BODY RADIATION THERAPY IN LOCALIZED DISEASE PROSTATE CANCER: PRELIMINARY RESULTS OF A PHASE-II STUDY

: Magnetic resonance imaging (MRI)-guided stereotactic body radiation therapy (SBRT) has been established as a safe and effective treatment for prostate cancer. The goal of prostate SBRT is to treat the entire prostate and proximal seminal vesicles, while limiting radiation dose to the adjacent crit...

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Bibliographic Details
Published in:Anticancer research 2018-04, Vol.38 (4), p.2493
Main Authors: Magli, Alessandro, Moretti, Eugenia, Guernieri, Marika, Girometti, Rossano, Urpis, Mauro, Crespi, Margherita, Ceschia, Tino, Signor, Marco Andrea, Foti, Claudio, Scalchi, Paolo, Trovò, Marco
Format: Article
Language:English
Subjects:
Acute toxicity
Biological effects
Bladder
Cancer
Cancer therapies
Computation
Computed tomography
Contouring
Contours
Delineation
Diaphragm
Gold
Health risks
Interfaces
Lymph nodes
Magnetic resonance imaging
Markers
Mathematical analysis
Medical imaging
Medical instruments
NMR
Nuclear magnetic resonance
Organs
Patients
Planning
Prostate cancer
Radiation
Radiation dosage
Radiation therapy
Rectum
Reduction
Resonance
Risk
Seminal vesicle
Toxicity
Tumors
Urethra
Vesicles
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Summary:: Magnetic resonance imaging (MRI)-guided stereotactic body radiation therapy (SBRT) has been established as a safe and effective treatment for prostate cancer. The goal of prostate SBRT is to treat the entire prostate and proximal seminal vesicles, while limiting radiation dose to the adjacent critical structures, including the bladder, rectum, and membranous urethra. Since the prostate apex is commonly involved with cancer, under-dosing this region would likely increase the risk of recurrence. MRI imaging better defines the prostate and reduces the overall target volume compared to Computed Tomography (CT) imaging. In addition, the prostatic-rectal and prostatic-bladder interfaces are better defined by MRI than by CT imaging. Furthermore, the more accurate delineation of the prostatic apex allows for dose reduction to the genitourinary diaphragm (GUD). A phase-II study of SBRT for localized prostate cancer at low-/intermediate- risk (according to NCCN score) and risk of lymph node involvement
ISSN:0250-7005
1791-7530