PO-0079 Urinary N-telopeptide Levels Are Not Associated With Vitamin D Status In Healthy Children

Background and aimsUrinary levels of N-telopeptide (NTx) have been reported to be a sensitive and specific marker of bone resorption. This cross-sectional study determined the urinary levels of NTx among healthy children living in Calgary and explored their relationship with age, sex and vitamin D s...

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Bibliographic Details
Published in:Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A275-A275
Main Authors: Stoian, CA, Mah, JK, Chin, AC, Khan, A
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Age
Body height
Bone resorption
Bone turnover
Children
Creatinine
Dietary intake
Enzyme-linked immunosorbent assay
Excretion
Minority & ethnic groups
Physical activity
Surgery
Vitamin D
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Summary:Background and aimsUrinary levels of N-telopeptide (NTx) have been reported to be a sensitive and specific marker of bone resorption. This cross-sectional study determined the urinary levels of NTx among healthy children living in Calgary and explored their relationship with age, sex and vitamin D status.MethodsWe included healthy children 2 to 13 years of age who presented to the Alberta Children’s Hospital for elective surgery during a 12-month period. Data including the child’s weight, height, age, gender, ethnicity, dietary intake, vitamin intake, and physical activity were collected. Urinary NTx levels were measured with a commercially (Wampole Laboratories, Princeton) available competitive-inhibition enzyme-linked immunosorbent assay.ResultsUrinary NTx levels were available for 968 out of 1862 participants, of whom 605 (62.5%) were boys. The mean urinary NTx/Creatinine ratio was 605.4 nmol/mmol (SD 264.8, range 200–2985.1). We found that mean urinary NTx/creatinine excretion was higher in the younger children (2–5 years) compared to subsequent ages. There was no significant difference in urinary NTx levels between children with suboptimal vitamin D status (serum 25-hydroxyvitamin D
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2014-307384.749