One Step Up in Antiproliferative Activity: The Ru‐Zn Complex [RuCp(PPh3)2‐µ‐dmoPTA‐1κP:2κ2N,N′‐ZnCl2](CF3SO3)

The synthesis, characterization and antiproliferative activity of the bimetallic Ru‐Zn complex [RuCp(PPh3)2‐µ‐dmoPTA‐1κP:2κ2N,N′‐ZnCl2](CF3SO3) (4) and the monometallic Ru complex [RuCp(PPh3)2(dmoPTA‐1κP)](CF3SO3) (5) are presented. Against human lung, cervix, breast, and colon solid tumor cell line...

Full description

Saved in:
Bibliographic Details
Published in:European journal of inorganic chemistry 2018-11, Vol.2018 (43), p.4684-4688
Main Authors: Mendoza, Zenaida, Lorenzo‐Luis, Pablo, Scalambra, Franco, Padrón, José M., Romerosa, Antonio
Format: Article
Language:English
Subjects:
Antiproliferation
Antiproliferatives
Bimetals
Breast cancer
Cancer
Cobalt compounds
Colon
Heterometallic complexes
Inorganic chemistry
PTA derivatives
Ruthenium
Ruthenium compounds
Selectivity
Tumors
Zinc chloride
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis, characterization and antiproliferative activity of the bimetallic Ru‐Zn complex [RuCp(PPh3)2‐µ‐dmoPTA‐1κP:2κ2N,N′‐ZnCl2](CF3SO3) (4) and the monometallic Ru complex [RuCp(PPh3)2(dmoPTA‐1κP)](CF3SO3) (5) are presented. Against human lung, cervix, breast, and colon solid tumor cell lines, complex 4 showed an enhanced antiproliferative activity (GI50 = 30–83 nm) when compared to its parent complex [RuCp(PPh3)2(HdmoPTA‐1κP)](CF3SO3) (2). Additionally, it was significantly more active against the breast cancer cell line T‐47D than its sibling cobalt complex [RuCp(PPh3)2‐µ‐dmoPTA‐1κP:2κ2N,N′‐CoCl2](CF3SO3) (3). When evaluated against non‐tumor human cell line BJ‐hTert, complex 4 was 3–8 times less active, indicating a large selectivity for tumor cells, while compound 5 was not selective. A new bimetallic complex, [RuCp(PPh3)2‐µ‐dmoPTA‐1κP:2κ2N,N′‐ZnCl2], shows 26–426 times more potent antiproliferative activity than cisplatin against a representative panel of human cancer cells.
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.201800857