Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice

We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treat...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-01, Vol.133 (1), p.68
Main Authors: Mikhailova, A A, Kirilina, E A, Morozova, O V, Turusov, V S
Format: Article
Language:English
Subjects:
Adenoma - etiology
Adenoma - mortality
Adenoma - prevention & control
Animals
Antineoplastic Agents - therapeutic use
Carcinogens
Lung Neoplasms - etiology
Lung Neoplasms - mortality
Lung Neoplasms - prevention & control
Male
Mice
Oligopeptides - therapeutic use
Urethane
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Summary:We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of spontaneous and urethane-induced lung tumors in mice. Myelopeptide-2 delayed the appearance of urethane-induced tumors irrespective of the number of injections.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1015164713174