In vivo evaluation of the genotoxicity and oxidative damage in individuals exposed to 10% hydrogen peroxide whitening strips

Objective This study assessed the impact of 10% hydrogen peroxide whitening strip exposure on the genotoxicity and oxidative damage by means of the buccal micronucleus cytome assay by counting nuclear abnormalities (NAs) in buccal mucosa and attached gingiva cells and by analyzing in whole saliva th...

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Bibliographic Details
Published in:Clinical oral investigations 2019-07, Vol.23 (7), p.3033-3046
Main Authors: Del Real García, José Francisco, Saldaña-Velasco, Fausto Rubén, Sánchez-de la Rosa, Susana Vanessa, Ortiz-García, Yveth Marlene, Morales-Velazquez, Gabriela, Gómez-Meda, Belinda Claudia, Zúñiga-González, Guillermo Moisés, Sánchez-Parada, María Guadalupe, Zamora-Perez, Ana Lourdes
Format: Article
Language:English
Subjects:
Bleaching
Buccal mucosa
Cosmetic dentistry
Dentistry
Deoxyguanosine
DNA damage
DNA Damage - ethics
Epithelial cells
Female
Genotoxicity
Humans
Hydrogen peroxide
Hydrogen Peroxide - toxicity
Male
Medicine
Micronuclei
Original Article
Oxidants - toxicity
Oxidation
Oxidative Stress
Saliva
Teeth
Tooth Bleaching - adverse effects
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Summary:Objective This study assessed the impact of 10% hydrogen peroxide whitening strip exposure on the genotoxicity and oxidative damage by means of the buccal micronucleus cytome assay by counting nuclear abnormalities (NAs) in buccal mucosa and attached gingiva cells and by analyzing in whole saliva the molecule 8-hydroxy-2′-deoxyguanosine (8-OHdG). Materials and methods The study was conducted on 113 subjects divided into two groups: group 1 or control ( n  = 53), non-whitening strip exposed, and group 2 ( n  = 60), whitening strip exposed (Crest® 3D Whitestrips® premium plus, 10% hydrogen peroxide). Oral epithelial cells and whole saliva samples were taken at the beginning and 30 days later for group 1 and immediately before bleaching and 15 and 30 days after the end of the bleaching for group 2. Results An increased frequency of NAs ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-018-2716-3