An aqueous medium-controlled stereospecific oxidative iodination of alkynes: efficient access to ( E )-diiodoalkene derivatives

A new and versatile approach for the stereospecific iodination of alkynes using cheap, air stable and non-toxic reagents in aqueous media has been developed. This protocol is tolerant of various functional groups, and provides a broad range of vicinal diiodoalkenes with exceptional E -selectivity un...

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Bibliographic Details
Published in:New journal of chemistry 2018, Vol.42 (22), p.17879-17883
Main Authors: Banothu, Rammurthy, Peraka, Swamy, Kodumuri, Srujana, Chevella, Durgaiah, Gajula, Krishna Sai, Amrutham, Vasu, Yennamaneni, Divya Rohini, Nama, Narender
Format: Article
Language:English
Subjects:
Alkynes
Functional groups
Iodination
Reagents
Selectivity
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Summary:A new and versatile approach for the stereospecific iodination of alkynes using cheap, air stable and non-toxic reagents in aqueous media has been developed. This protocol is tolerant of various functional groups, and provides a broad range of vicinal diiodoalkenes with exceptional E -selectivity under mild conditions. Scale-up reactions (up to 5 g) established the proficiency of this protocol and highlight the feasibility of large scale reactions.
ISSN:1144-0546
1369-9261
DOI:10.1039/C8NJ03929A