Comparison of coronary thermodilution and doppler velocity for assessing coronary flow reserve

Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute fl...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-11, Vol.108 (18), p.2198-2200
Main Authors: FEARON, William F, FAROUQUE, H. M, BALSAM, Leora B, COOKE, David T, ROBBINS, Robert C, FITZGERALD, Peter J, YEUNG, Alan C, YOCK, Paul G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity
Blood Pressure
Cardiology. Vascular system
Coronary Circulation
Coronary Stenosis - diagnosis
Coronary Stenosis - physiopathology
Disease Models, Animal
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Hyperemia - chemically induced
Hyperemia - diagnosis
Hyperemia - physiopathology
Linear Models
Medical sciences
Microspheres
Papaverine
Predictive Value of Tests
Swine
Thermodilution
Ultrasonography, Doppler
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Summary:Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear. In an open-chest pig model, CFRthermo was measured in the left anterior descending (LAD) artery and compared with CFRDoppler and CFRflow, measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFRthermo correlated strongly with the reference standard CFRflow (r=0.85, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000099521.31396.9d