Applicability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease

Background Studies have demonstrated that troponin T is a strong independent indicator of a poor prognosis in patients with unstable coronary artery disease. Up to the present, no study has compared the prognostic value of troponin T with that of troponin I in the same cohort of patients. Methods an...

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Published in:Circulation (New York, N.Y.) N.Y.), 1997-10, Vol.96 (8), p.2578-2585
Main Authors: LÜSCHER, M. S, THYGESEN, K, RAVKILDE, J, HEICKENDORFF, L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Heart
Medical sciences
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Summary:Background Studies have demonstrated that troponin T is a strong independent indicator of a poor prognosis in patients with unstable coronary artery disease. Up to the present, no study has compared the prognostic value of troponin T with that of troponin I in the same cohort of patients. Methods and Results Patients (n=516) suspected of having unstable coronary artery disease were investigated. Follow-up was done after 30 days, and the occurrences of cardiac death, acute myocardial infarction, refractory angina pectoris, and recurrent angina pectoris were registered. Elevated levels of troponin T (≥0.10 μg/L) were associated with an increased risk of cardiac death at 30 days compared with patients with normal levels, 3.2% versus 0.4% ( P =.014). Troponin I values above the chosen cutoff (2.0 μg/L) were similarly found to be an indicator of increased risk of cardiac death, 3.2% versus 0.7% ( P =.026). With regard to the composite end point of cardiac death/acute myocardial infarction, the troponins were strong independent indicators of adverse outcome. Conclusions In patients suspected of having unstable coronary artery disease, both troponin T and troponin I provide independent prognostic information with regard to cardiac death and acute myocardial infarction.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.96.8.2578