A highly selective turn-on fluorescent and naked-eye colorimetric sensor for cyanide detection in food samples and its application in imaging of living cells

[Display omitted] •A highly selective oligothiophene-benzothiazole based sensor 3TBN has been developed.•Sensor 3TBN shows naked-eye colorimetric and fluorescence turn-on response toward CN−.•Paper-based colorimetric test strips of 3TBN were fabricated to effectively detect CN− in water.•Sensor 3TBN...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2018-12, Vol.276, p.13-22
Main Authors: Niu, Qingfen, Lan, Linxin, Li, Tianduo, Guo, Zongrang, Jiang, Tao, Zhao, Zhiyi, Feng, Zhenshuai, Xi, Jinying
Format: Article
Language:English
Subjects:
Anions
Bioimaging
Biosensors
Cell culture
Cells
Colorimetric
Colorimetry
Cyanide
Cyanides
Cytotoxicity
Fluorescence
Fluorescence in situ hybridization
Fluorescent sensor
Food
Food samples
Medical imaging
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Summary:[Display omitted] •A highly selective oligothiophene-benzothiazole based sensor 3TBN has been developed.•Sensor 3TBN shows naked-eye colorimetric and fluorescence turn-on response toward CN−.•Paper-based colorimetric test strips of 3TBN were fabricated to effectively detect CN− in water.•Sensor 3TBN has been successfully employed for CN− detection in food samples.•Sensor 3TBN can be used for determination of CN− in living cells. A novel highly selective oligothiophene-benzothiazole based sensor 3TBN has been developed for “naked-eye” colorimetric and fluorescent “turn-on” detection of cyanide in aqueous DMSO media. The sensor 3TBN exhibited distinct visual color and spectral changes in response to cyanide anion (CN−) over other tested anions. A good linear relationship was clearly observed between the fluorescence enhancement of the sensor 3TBN and the concentration of CN− in the wide range of 0–40 μM with a low detection limit of 0.46 μM. The sensing mechanism based on the nucleophilic addition reaction of the sensor with CN− on the cyanovinyl electrophilic CC group has been well confirmed. Economically viable paper-based colorimetric test strips of 3TBN were fabricated to effectively detect the CN− ions in water. More importantly, as a cost-effective and selective fluorescent sensor, the sensor 3TBN has been successfully employed for detection of CN− in food samples and fluorescence bioimaging in living HeLa cells.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2018.08.066