Loading of Fluvastatin onto Gelatin-Coated Titanium Implants

We aimed to investigate the effects of alumina blasting and alkaline treatment on the immobilization of gelatin-fluvastatin complexes on titanium disks. Blasted titanium disks were submicron-sized porous while the alkaline treated disks were submicron-and nanoporous. XPS analysis revealed homogeneou...

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Bibliographic Details
Published in:Key engineering materials 2018-10, Vol.782, p.233-237
Main Authors: Takemoto, Shinji, Yoshinari, Masao, Sugawara, Shiho, Jansen, John J., Sasaki, Kaori, Taira, Masayuki, Tanabe, Koji, Hattori, Masayuki, Saitoh, Setsuo, Sawada, Tomofumi, Leeuwenburgh, Sander G.G.
Format: Article
Language:English
Subjects:
Dental implants
Gelatin
Surgical implants
Titanium
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Summary:We aimed to investigate the effects of alumina blasting and alkaline treatment on the immobilization of gelatin-fluvastatin complexes on titanium disks. Blasted titanium disks were submicron-sized porous while the alkaline treated disks were submicron-and nanoporous. XPS analysis revealed homogeneous coverage of titanium disks with a gelatin layer on top of an intermediate polydopamine treatment. The highest amount of fluvastatin immobilization was observed on top of alkaline treated titanium as compared to the blasted disk. A combination of alkaline pre-treatment followed by polydopamine-assisted immobilization of gelatin facilitated optimal loading of fluvastatin onto titanium dental implants.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.782.233