Effects of boric acid on bone formation after maxillary sinus floor augmentation in rabbits

Purpose Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental stu...

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Bibliographic Details
Published in:Oral and maxillofacial surgery 2018-12, Vol.22 (4), p.443-450
Main Authors: Ulu, Murat, Kütük, Nükhet, Cıcık, Muhammet Furkan, Bilge, Suheyb, Akçay, Hüseyin, Saygılı, Suna, Tuğlu, Mehmet İbrahim, Alkan, Alper
Format: Article
Language:English
Subjects:
Acids
Administration, Oral
Animals
Bone Substitutes - administration & dosage
Bone Substitutes - therapeutic use
Bone Transplantation - methods
Boric Acids - administration & dosage
Boric Acids - therapeutic use
Male
Maxillary Sinus - anatomy & histology
Maxillary Sinus - drug effects
Maxillary Sinus - surgery
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Original Article
Osteogenesis - drug effects
Rabbits
Sinus Floor Augmentation - methods
Sinuses
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Summary:Purpose Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA). Materials and methods Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3. Results The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups ( p   0.05). Conclusion Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
ISSN:1865-1550
1865-1569
DOI:10.1007/s10006-018-0729-3