Curcumin incorporated PVA‐borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate

ABSTRACT Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and netwo...

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Bibliographic Details
Published in:Journal of applied polymer science 2018-12, Vol.135 (45), p.n/a
Main Authors: Rezvan, Gelareh, Pircheraghi, Gholamreza, Bagheri, Reza
Format: Article
Language:English
Subjects:
Biocompatibility
Borax
Correlation analysis
Crosslinking
Drug delivery systems
Fourier transforms
hydrogel
Hydrogels
Materials science
Micelles
Poloxamers
Polymers
Properties (attributes)
rheology
Shear flow
Silicon
Spectrum analysis
structure‐property relationships
Viscoelasticity
Wound healing
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Summary:ABSTRACT Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA‐Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a hydrophobic drug was encapsulated in Pluronic F127 micelles and then these nano carriers (Cur‐P) were loaded into prepared hydrogels. The curcumin release rate in PBS solution was investigated by UV–vis spectroscopy measurements. The strong power law correlation between curcumin release rate and viscoelastic properties of PB hydrogel was confirmed. This drug delivery vehicle can be used as a competent wound dress. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46734.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.46734