Analysis of virological, histological and clinical features of hepatitis delta virus infection in Southeastern Turkey

Objectives: The present study aims to investigate biochemical, virological and histological characteristics of hepatitis delta virus infection, which is a serious problem in our region, as well as its relationship with chronic hepatitis B virus (HBV) infection and cirrhosis. Materials and Methods: A...

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Bibliographic Details
Published in:Viral hepatit dergisi 2018-08, Vol.24 (2), p.47-52
Main Authors: Yalçın,Mehmet Suat, Yalçın,Kendal
Format: Article
Language:eng ; tur
Subjects:
Age
Antigens
Epidemiology
Females
Gastroenterology
Genetic diversity
Hematology
Hepatitis
Hepatitis delta virus
Hepatology
Infections
Interferon
Laboratories
Liver cancer
Liver cirrhosis
Liver diseases
Polymerase chain reaction
Statistical analysis
Tıp
Ultrasonic imaging
Viruses
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Summary:Objectives: The present study aims to investigate biochemical, virological and histological characteristics of hepatitis delta virus infection, which is a serious problem in our region, as well as its relationship with chronic hepatitis B virus (HBV) infection and cirrhosis. Materials and Methods: A total of 220 patients were included in the study. The patients were divided into three groups: group 1 included patients with hepatitis delta virus-related cirrhosis (DA cirrhosis), group 2 consisted of patients with chronic delta hepatitis (CHD) and group 3 composed of patients with chronic hepatitis B (CHB). Biochemical and virological parameters of the patients were analyzed. Patients with CHB and CHD underwent biopsy for histological examination. The results were compared among the three groups. Results: Seventy-five (34.09%) of the patients were women, 145 (65.90%) were males and their mean age was 38.04 years. There were 44 patients (20%) with delta hepatitis-associated cirrhosis, 86 patients with CHD (39.09%) and 90 patients with CHD (40.9%). HBV DNA level was significantly lower in patients with cirrhosis and chronic delta hepatitis than in patients with CHB (p
ISSN:1307-9441
2147-2939
DOI:10.4274/vhd.2018.0005