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Predictors of Early Discontinuation of Interferon-Free Direct Antiviral Agents in Patients With HCV and Advanced Fibrosis: Results of A Real-Life Cohort
OBJECTIVES: To determinate risk factors for premature treatment discontinuation among patients infected with HCV with advanced fibrosis treated with IFN-free direct antiviral agents (DAA)-based therapy. METHODS: We included all patients with chronic HCV infection and advanced fibrosis who initiated...
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Published in: | Value in health 2017-10, Vol.20 (9), p.A926-A927 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | OBJECTIVES: To determinate risk factors for premature treatment discontinuation among patients infected with HCV with advanced fibrosis treated with IFN-free direct antiviral agents (DAA)-based therapy. METHODS: We included all patients with chronic HCV infection and advanced fibrosis who initiated treatment with IFN-free DAA therapy at an university hospital from December 2015 through June 2016. We prospectively collected data from medical records using standardized questionnaires and evaluated them using Epilnfo 7.1.2.0. Primary outcome was treatment interruption and factors associated. RESULTS: Of total, 214 patients were included in this study, 180 patients treated with sofosbuvir(SOF) + daclatasvir ± ribavirin(RBV), 31 received SOF + simeprevir ± RBV, and 3 treated with SOF+RBV Treatment discontinuation rate was 8.9% (19), and cirrhotic decompensation was the main reason (8; 42.1%). Among patients with Child B or C cirrhosis (31), 10 (32.2%) prematurely interrupted treatment. Risk factors for treatment discontinuation in univariate analysis were higher age (p 0.0252), higher comorbidity index (p 0.0078), higher Model for end stage liver disease (MELD) (p |
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ISSN: | 1098-3015 1524-4733 |
DOI: | 10.1016/j.jval.2017.08.3091 |