Ventricular bigeminal rhythm associated with trastuzumab: A potential cardiac side effect

Cardiac side effects of targeted chemotherapy agents are getting more and more important topic nowadays. However, the studies on this topic are limited. Because multiple agent chemotherapy is not a common treatment option, it is hard to establish controlled study groups (as before chemotherapy and a...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2018-06, Vol.14 (9), p.536-537
Main Authors: Karaca, Mustafa, Kocoglu, Hakan, Bilgetekin, Irem, Ozet, Ahmet, Sahinli, Hayriye, Demir, Hacer, Kankoc, Aykut, Tural, Deniz, Yucel, Orhan
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Immunological - adverse effects
Antineoplastic Agents, Immunological - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Arrhythmias, Cardiac - diagnosis
Arrhythmias, Cardiac - etiology
Biomarkers
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - diagnosis
Breast Neoplasms - drug therapy
Chemotherapy
Echocardiography
Electrocardiography
Female
Gene amplification
Heart failure
Humans
Immunotherapy
Middle Aged
Monoclonal antibodies
Patient outcomes
Patients
Sinuses
Targeted cancer therapy
Trastuzumab
Trastuzumab - adverse effects
Trastuzumab - therapeutic use
Ultrasonic imaging
Ventricular Dysfunction - diagnosis
Ventricular Dysfunction - etiology
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Summary:Cardiac side effects of targeted chemotherapy agents are getting more and more important topic nowadays. However, the studies on this topic are limited. Because multiple agent chemotherapy is not a common treatment option, it is hard to establish controlled study groups (as before chemotherapy and after chemotherapy); further, cancer, itself, may cause cardiac side effects and uncertainty of the symptoms may be associated with previous clinical situation before chemotherapy. For all that, we may get information to a certain degree about the side effects of these agents by analyzing case reports. These side effects have a broad spectrum from asymptomatic rhythm alterations to acute cardiac death. In this case report, we aim to discuss asymptomatic ventricular bigeminal rhythm, which is proved by electrocardiography, of our patient during treated by trastuzumab.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.183557