Neuroprotective Effect of Curcumin on LPS-activated Astrocytes Is Related to the Prevention of GFAP and NF-κB Upregulation

We examined the effects of 2.0 μM curcumin, a known antioxidant, on the cultures of normal rat astrocytes and of those subjected to the action of 0.01 μM lipopolysaccharide, LPS. As was found, 24-h-long exposure of astrocytes to LPS resulted in a relatively mild decrease in the cell viability of ast...

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Bibliographic Details
Published in:Neurophysiology (New York) 2017-08, Vol.49 (4), p.305-307
Main Authors: Nedzvetsky, V. S., Agca, C. A., Kyrychenko, S. V.
Format: Article
Language:English
Subjects:
Antioxidants
Astrocytes
Biomedical and Life Sciences
Biomedicine
Curcumin
Cytoskeleton
Glial fibrillary acidic protein
Lipopolysaccharides
Neurobiology
Neuroprotection
Neurosciences
NF-κB protein
Poly(ADP-ribose) polymerase
Ribose
Up-regulation
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Summary:We examined the effects of 2.0 μM curcumin, a known antioxidant, on the cultures of normal rat astrocytes and of those subjected to the action of 0.01 μM lipopolysaccharide, LPS. As was found, 24-h-long exposure of astrocytes to LPS resulted in a relatively mild decrease in the cell viability of astrocytes (a decrement of 22%). The action of curcumin significantly ameliorated this decrease. LPS induced significant upregulation of GFAP, NF-κB, and poly(ADP-ribose)polymerase (PARP) in activated astrocytes. Curcumin significantly decreased these effects (to 60, 71, and 89% as compared to those in astrocytes subjected to isolated action of LPS). Thus, curcumin significantly prevents the decrease in cell viability and moderates the cytoskeleton rearrangements and disorders in NF-κBdependent regulation in astrocytes activated by LPS.
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-017-9687-x