Augmentation of LTC4 synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro

We assessed the effect of anti-CD3-stimulated secretion of cultured human Th1- and Th2-like cells on leukotriene C4 (LTC4) secretion in isolated human eosinophils. T hleper (Th) cell subsets were generated from human naive CD4(+) T cells cocultured with irradiated human transformed B cells and eithe...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-06, Vol.22 (6), p.L1172-L1179
Main Authors: MUNOZ, N. M, VAN SEVENTER, G. A, SEMNANI, R. T, LEFF, A. R
Format: Article
Language:English
Subjects:
Allergies
Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Cell interactions
Cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Pathology
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Summary:We assessed the effect of anti-CD3-stimulated secretion of cultured human Th1- and Th2-like cells on leukotriene C4 (LTC4) secretion in isolated human eosinophils. T hleper (Th) cell subsets were generated from human naive CD4(+) T cells cocultured with irradiated human transformed B cells and either recombinant human interleukin (rhIL)-1beta plus rhIL-6 plus rhIL-12 for Th1-like cells or rhIL-1beta plus rhIL-6 plus rhIL-4 for Th2-like cells.
ISSN:1040-0605
1522-1504