Fluctuations in vancomycin CNS tissue concentrations following intermittent and continuous infusions in the rat

The purpose of this investigation was to compare the variability of vancomycin concentrations in the serum and CNS when administered continuously or as intermittent intravenous infusions in the rat. The hypothesis for this investigation was that the magnitude of change in serum vancomycin concentrat...

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Bibliographic Details
Published in:Neurological research (New York) 2004-04, Vol.26 (3), p.312-315
Main Authors: Luer, Mark S., Neill, Kathryn K., Gurley, Billy J., Lamb Shannon, Melissa, Killian, Aaron D., Rodvold, Keith A.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacokinetics
BRAIN
Central Nervous System - metabolism
Chromatography, Liquid - methods
CONTINUOUS INFUSION
Drug Administration Schedule
Drug Monitoring
Infusions, Intravenous
Male
MICRODIALYSIS
Microdialysis - methods
Rats
Rats, Sprague-Dawley
Tissue Distribution
VANCOMYCIN
Vancomycin - pharmacokinetics
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Summary:The purpose of this investigation was to compare the variability of vancomycin concentrations in the serum and CNS when administered continuously or as intermittent intravenous infusions in the rat. The hypothesis for this investigation was that the magnitude of change in serum vancomycin concentrations directly relates to the extent of vancomycin concentration fluctuations in the CNS. Microdialysis and serum sampling techniques were employed and biologic samples were analysed for vancomycin using HPLC. Over the dosing interval, the mean changes in concentrations were 71.8 ± 9.8% and 13.6 ± 9.3% for serum and 61.7 ± 7.8% and 6.8 ± 3.5% for brain extracellular fluid in the intermittent and continuously infused groups, respectively. Accordingly, the relative changes in vancomycin concentrations in brain extracellular fluid were closely associated with corresponding changes in serum concentrations (R 2 =0.94). Thus, continuous intravenous administration of vancomycin results in minimal serum and CNS tissue concentration changes as compared to traditional intermittent dosing methods and allows for more consistent vancomycin concentrations in the CNS.
ISSN:0161-6412
1743-1328
DOI:10.1179/016164104225014012