Erythropoietin, progenitors, and repair

The erythropoietin–erythropoietin-receptor (EPO–EPO-R) system has recently been identified as an important cellular survival pathway. Its presence has also been demonstrated in the kidney and identified as a therapeutic target to prevent loss of renal function. Part of the protective effects may be...

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Bibliographic Details
Published in:Kidney international 2007-11, Vol.72 (S107), p.S16-S20
Main Authors: Aydin, Z., Duijs, J., Bajema, I.M., van Zonneveld, A.J., Rabelink, T.J.
Format: Article
Language:English
Subjects:
endothelial progenitor cell
endothelium
erythropoietin
erythropoietin-receptor
renal failure
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Summary:The erythropoietin–erythropoietin-receptor (EPO–EPO-R) system has recently been identified as an important cellular survival pathway. Its presence has also been demonstrated in the kidney and identified as a therapeutic target to prevent loss of renal function. Part of the protective effects may be related to the action of erythropoietin on endothelial function and expansion of endothelial progenitor cells. This paper reviews current evidence for involvement of these mechanisms in EPO-mediated renoprotection.
ISSN:0085-2538
1523-1755
DOI:10.1038/sj.ki.5002483