The Research of Physicochemical Properties and Determination of Nano-L-DOPA Quality Attributes Based on PLGA Nanoparticles for the Treatment of Parkinson's Disease

Chromatographic conditions are as follows: the column - Zorbax Eclipse XDB-C18 (150X4.6 mm; 5 pm); the mobile phase consists of a mixture of A and B solutions (solution A - phosphate buffer, pH = 2.54, solution B - acetonitrile); the column temperature - 30 °C; flow rate - 0.8 ml/min; detector - UV...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2018-06, Vol.10 (6), p.1457-1460
Main Authors: Pavlov, A N, Pyatigorskaya, N V, Brkich, G E, Kedik, S A, Panov, A V
Format: Article
Language:English
Subjects:
Alzheimer's disease
Bioavailability
Efficiency
Laboratories
Methods
Neurosciences
Parkinson's disease
Pharmaceuticals
Polymers
Polyvinyl alcohol
Retention
Spectrum analysis
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Summary:Chromatographic conditions are as follows: the column - Zorbax Eclipse XDB-C18 (150X4.6 mm; 5 pm); the mobile phase consists of a mixture of A and B solutions (solution A - phosphate buffer, pH = 2.54, solution B - acetonitrile); the column temperature - 30 °C; flow rate - 0.8 ml/min; detector - UV 280 nm; the volume of the injected sample - 10 pi; the sample temperature - 4 °C; the run time - 35 min; and the L-Dopa retention time - about 8 min. The drugs enter the bloodstream, avoiding the primary passage through the liver. [...]some drugs can be transported from the nasal cavity to the central nervous system, not through the circulatory system of the nasal cavity mucosa, but through the extracellular path along the olfactory nerve to penetrate directly into the brain, bypassing the BBB [10, 11]. [...]the nasal delivery route provides new opportunities for the treatment of neurodegenerative diseases of the brain [12]. [...]of the systematization of the data obtained, the main quality attributes and methods for analyzing Nano-L-Dopa have been proposed.
ISSN:0975-1459