Growth of CuO nanoneedles on graphene quantum dots as peroxidase mimics for sensitive colorimetric detection of hydrogen peroxide and glucose

•GQDs/CuO nanocomposites are facilely fabricated by the growth of CuO nanoparticles on GQDs.•GQDs/CuO nanocomposites could be used as effective peroxidase mimics for the detection of H2O2 and glucose.•Detection limit of GQDs/CuO nanocomposites for glucose is down to 0.59μM. Graphene quantum dots-cop...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2017-09, Vol.248, p.374-384
Main Authors: Zhang, Li, Hai, Xin, Xia, Chang, Chen, Xu-Wei, Wang, Jian-Hua
Format: Article
Language:English
Subjects:
Catalysis
Colorimetric detection
Colorimetry
Copper oxides
Enzyme kinetics
Enzyme mimics
Enzymes
Glucose
Glucose oxidase
GQDs/CuO nanocomposites
Graphene
H2O2
Hydrogen
Hydrogen peroxide
Methane biosynthesis
Nanocomposites
Oxidation
Peroxidase
Quantum dots
Synthesis gas
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Summary:•GQDs/CuO nanocomposites are facilely fabricated by the growth of CuO nanoparticles on GQDs.•GQDs/CuO nanocomposites could be used as effective peroxidase mimics for the detection of H2O2 and glucose.•Detection limit of GQDs/CuO nanocomposites for glucose is down to 0.59μM. Graphene quantum dots-copper oxide nanocomposites (GQDs/CuO) are facilely fabricated by the growth of CuO nanoneedles on graphene quantum dots under mild conditions. The as-prepared GQDs/CuO nanocomposites could be used as an effective peroxidase mimics to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to produce a blue-colored solution. Investigations on the mechanism indicate that the nature of peroxidase-like activity of GQDs/CuO nanocomposites originates from OH radical generation. The increase of absorbance at 652nm induced by the catalytic effect of GQDs/CuO nanocomposites offers accurate detection of H2O2 in the range of 0.5–10μM, along with a detection limit of 0.17μM. A colorimetric method for serum glucose detection is also proposed by combining the GQDs/CuO catalytic reaction and the enzymatic oxidation of glucose with glucose oxidase. This method is simple, sensitive and selective for glucose detection with a linear range from 2 to 100μM with a detection limit of 0.59μM.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2017.04.011