Zafirlukast Pocket Delivery Impairs the Capsule Healing Around Textured Implants in Rats

Background The aim of this study was to investigate the effects of zafirlukast on capsule thickness, collagen fiber density, and myofibroblast cell count of the healing tissue around silicone textured implants in rats. Methods Thirty-six male Wistar rats were divided ( n  = 18) into two groups. In o...

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Bibliographic Details
Published in:Aesthetic plastic surgery 2009, Vol.33 (1), p.90-97
Main Authors: Moreira, Marcio, Fagundes, Djalma José, de Jesus Simões, Manuel, de Oliveira, Mônica Cristina Baiardi Mizoguti, dos Santos Previdelli, Isolde Terezinha, Moreira, Amanda Castilho
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Breast Implants
Cell Count
Collagen - drug effects
Collagen - metabolism
Disease Models, Animal
Drug Administration Routes
Fibroblasts - drug effects
Fibroblasts - pathology
Immunohistochemistry
Leukotriene Antagonists - adverse effects
Leukotriene Antagonists - pharmacology
Male
Medicine
Medicine & Public Health
Original Article
Otorhinolaryngology
Plastic Surgery
Prosthesis Design
Random Allocation
Rats
Rats, Wistar
Reference Values
Risk Assessment
Sensitivity and Specificity
Silicone Gels
Time Factors
Tosyl Compounds - adverse effects
Tosyl Compounds - pharmacology
Wound Healing - drug effects
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Summary:Background The aim of this study was to investigate the effects of zafirlukast on capsule thickness, collagen fiber density, and myofibroblast cell count of the healing tissue around silicone textured implants in rats. Methods Thirty-six male Wistar rats were divided ( n  = 18) into two groups. In one group, two parallel incisions (1.5 cm long) were made into the right and left sides of the spine. Two pockets were then created in which shell-shaped textured implants were inserted. The left-side pocket was injected with 0.2 ml of saline solution (SSG) and the right-side pocket with a dose of 1.25 mg/kg of zafirlukast (ZLG). The other 18 rats (sham, SG) had only one pocket created, followed by the placement of an implant and injection of 0.2 ml of saline solution. The rats were euthanized on the 7th, 35th, or 90th days followed by careful dissection of the implant. The capsules and peri-implant tissues were prepared for histologic analysis. An ANOVA test and Tukey test were applied ( p  
ISSN:0364-216X
1432-5241
DOI:10.1007/s00266-008-9245-4