Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial

Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we...

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Bibliographic Details
Published in:The Lancet (British edition) 2004-11, Vol.364 (9449), p.1945-1949
Main Authors: Van Overmeire, Bart, Allegaert, Karel, Casaer, Alexandra, Debauche, Christian, Decaluwé, Wim, Jespers, Ann, Weyler, Joost, Harrewijn, Inge, Langhendries, Jean-Paul
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Babies
Birth weight
Cerebral Hemorrhage - prevention & control
Cerebral Ventricles
Clinical trials
Congenital diseases
Coronary vessels
Creatinine
Cyclooxygenase Inhibitors - adverse effects
Cyclooxygenase Inhibitors - therapeutic use
Data collection
Double-Blind Method
Double-blind studies
Drug dosages
Drug therapy
Ductus Arteriosus, Patent - prevention & control
Evidence-based medicine
Gestational age
Hemorrhage
Hospitals
Humans
Ibuprofen
Ibuprofen - adverse effects
Ibuprofen - analogs & derivatives
Ibuprofen - therapeutic use
Infant, Newborn
Infant, Premature, Diseases - prevention & control
Infants
Lysine
Lysine - adverse effects
Lysine - analogs & derivatives
Lysine - therapeutic use
Motivation
Nonsteroidal anti-inflammatory drugs
Premature birth
Prophylaxis
Side effects
Ultrasonic imaging
Urine
Ventilators
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Summary:Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed to study the efficacy of early ibuprofen in reducing these outcomes in a double-blind, multicentre trial. Within 6 h after birth, 415 low-birthweight infants (gestational age
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(04)17477-1