Radiofrequency electromagnetic radiation exposure effects on amygdala morphology, place preference behavior and brain caspase-3 activity in rats

•Chronic 900 MHz exposure perturbed cellular architecture of rat amygdala.•Number of healthy neurons decreased in basolateral, cortical nuclei but not in central nuclei.•Dendritic arborization of basolateral neurons was found to be reduced.•This was associated with altered place preference behavior....

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2018-03, Vol.58, p.220-229
Main Authors: Narayanan, Sareesh Naduvil, Mohapatra, Nirupam, John, Pamala, K., Nalini, Kumar, Raju Suresh, Nayak, Satheesha B., Bhat, P. Gopalakrishna
Format: Article
Language:English
Subjects:
Amygdala
Animals
Apoptosis
Apoptosis - radiation effects
Behavior, Animal - radiation effects
Brain
Brain - metabolism
Brain - pathology
Brain - radiation effects
Caspase
Caspase 3 - metabolism
Caspase-3
Cellular telephones
Conditioning, Operant - radiation effects
Cortex
Dendritic branching
Electromagnetic Radiation
Electromagnetism
Emotional behavior
Exposure
Hyperactivity
Male
Mobile phone
Morphology
Neurons
Neurons - pathology
Neurons - radiation effects
Place preference
Proteases
Radiation
Radiation effects
Radio frequency
Radiofrequency electromagnetic radiation
Rats
Rats, Wistar
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Summary:•Chronic 900 MHz exposure perturbed cellular architecture of rat amygdala.•Number of healthy neurons decreased in basolateral, cortical nuclei but not in central nuclei.•Dendritic arborization of basolateral neurons was found to be reduced.•This was associated with altered place preference behavior.•Brain caspase-3 was not found to be altered after chronic radiation exposure. The purpose of the study was to evaluate the changes in amygdala morphology and emotional behaviors, upon exposure to chronic RF-EMR in adolescent rats. Four weeks old male albino Wistar rats were exposed to 900 MHz (power density:146.60 μW/cm2) from a mobile phone in silent-mode for 28 days. Amygdala morphology was studied using cresyl violet, TUNEL and Golgi-Cox staining. Place preference behavior was studied using light/dark chamber test and following this brain caspase-3 activity was determined. Number of healthy neurons was decreased in the basolateral amygdala and cortical amygdala but not in the central amygdala after RF-EMR exposure. It also induced apoptosis in the amygdala. RF-EMR exposure altered dendritic arborization pattern in basolateral amygdala but not in the central amygdala. Altered place preference and hyperactivity-like behavior was evident after RF-EMR exposure, but brain caspase-3 activity did not change. RF-EMR exposure perturbed normal cellular architecture of amygdala and this was associated with altered place preference.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2018.01.009