Mortality in elderly patients with subclinical hyperthyroidism

Toft and Beckett, and Fowler highlight the issue of thyroxine replacement. Díez, in commenting on the variation in thyrotropin values over time, and Toft, in criticising us for not satisfying the definition of subclinical hyperthyroidism, are essentially referring to the difficulty of defining what...

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Bibliographic Details
Published in:The Lancet (British edition) 2002-03, Vol.359 (9308), p.799-799
Main Authors: Parle, James V, Maisonneuve, Patrick, Sheppard, Michael C, Boyle, Peter, Franklyn, Jayne A
Format: Article
Language:English
Subjects:
Geriatrics
Hyperthyroidism
Mortality
Older people
Thyroid gland
Online Access:Get full text
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Summary:Toft and Beckett, and Fowler highlight the issue of thyroxine replacement. Díez, in commenting on the variation in thyrotropin values over time, and Toft, in criticising us for not satisfying the definition of subclinical hyperthyroidism, are essentially referring to the difficulty of defining what is normal and what is abnormal. [...]just as it would be incorrect to use the standard statistical approach to determine normal and abnormal (as in treat/not treat) for, say, blood pressure in elderly people because many patients who need treatment would not receive it, so with thyroid function the prognostic importance of test results for thyroid-function must be identified to truly find the normal-abnormal decision point.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(02)07859-5