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Hydroxy- and alkoxymethylation of polyfluoroalkyl pyrazoles

A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles via regioselective N -hydroxy- and alkoxymethylation of N -unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydro...

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Bibliographic Details
Published in:Russian chemical bulletin 2018-03, Vol.67 (3), p.521-524
Main Authors: Ivanova, А. Е., Shchegol´kov, E. V., Burgart, Ya. V., Saloutin, V. I.
Format: Article
Language:English
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Summary:A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles via regioselective N -hydroxy- and alkoxymethylation of N -unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydroxymethylation requires anhydrous conditions.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2104-9