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Hydroxy- and alkoxymethylation of polyfluoroalkyl pyrazoles
A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles via regioselective N -hydroxy- and alkoxymethylation of N -unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydro...
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Published in: | Russian chemical bulletin 2018-03, Vol.67 (3), p.521-524 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles
via
regioselective
N
-hydroxy- and alkoxymethylation of
N
-unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydroxymethylation requires anhydrous conditions. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-018-2104-9 |