Racemic indole alkaloids from the seeds of Peganum harmala

Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A–E (1–5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantu...

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Bibliographic Details
Published in:Fitoterapia 2018-03, Vol.125, p.155-160
Main Authors: Wang, Kai-Bo, Hu, Xu, Li, Sheng-Ge, Li, Xin-Yu, Li, Da-Hong, Bai, Jiao, Pei, Yue-Hu, Li, Zhan-Lin, Hua, Hui-Ming
Format: Article
Language:English
Subjects:
Alkaloids
Carbon
Cytotoxicity
Herbal medicine
Indole alkaloid
Indoles
Natural products
Organic chemistry
Peganum harmala
Quantum chemistry
Seeds
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Summary:Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A–E (1–5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2018.01.008