Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specif...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (48), p.6161-6164
Main Authors: Shivatare, Sachin S, Huang, Lin-Ya, Zeng, Yi-Fang, Liao, Jung-Yu, You, Tsai-Hong, Wang, Shi-Yun, Cheng, Ting, Chiu, Chih-Wei, Chao, Ping, Chen, Li-Tzu, Tsai, Tsung-I, Huang, Chiu-Chen, Wu, Chung-Yi, Lin, Nan-Horng, Wong, Chi-Huey
Format: Article
Language:English
Subjects:
Antibodies
Glycan
Mannose
Substrates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specificity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03384f