Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

It is reported that in the absence of alphabeta T cells, B cells expand, differentiate and secrete copious amounts of antibodies of "T-dependent" isotypes. Antibodies are reactive towards self-antigens, as in patients with systemic lupus erythematosus.

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Published in:Nature (London) 1994-06, Vol.369 (6482), p.654-658
Main Authors: Wen, Li, Roberts, Scott J, Viney, Joanne L, Wong, F. Susan, Mallick, Caroline, Findly, R. Craig, Peng, Qingshuang, Craft, Joseph E, Owen, Michael J, Mayday, Adrian C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellular biology
Experimental and animal immunopathology. Animal models
Immunity (Disease)
Immunopathology
Medical sciences
Rodents
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cited_by cdi_FETCH-LOGICAL-c219t-65c3f4ce9f39bbe60cbbc113a72c9f3e10b88b6a163f3f8348f060a61fe8c75f3
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container_title Nature (London)
container_volume 369
creator Wen, Li
Roberts, Scott J
Viney, Joanne L
Wong, F. Susan
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Mayday, Adrian C
description It is reported that in the absence of alphabeta T cells, B cells expand, differentiate and secrete copious amounts of antibodies of "T-dependent" isotypes. Antibodies are reactive towards self-antigens, as in patients with systemic lupus erythematosus.
doi_str_mv 10.1038/369654a0
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source Springer Nature - Connect here FIRST to enable access
subjects Biological and medical sciences
Cellular biology
Experimental and animal immunopathology. Animal models
Immunity (Disease)
Immunopathology
Medical sciences
Rodents
title Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells
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