Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

It is reported that in the absence of alphabeta T cells, B cells expand, differentiate and secrete copious amounts of antibodies of "T-dependent" isotypes. Antibodies are reactive towards self-antigens, as in patients with systemic lupus erythematosus.

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Bibliographic Details
Published in:Nature (London) 1994-06, Vol.369 (6482), p.654-658
Main Authors: Wen, Li, Roberts, Scott J, Viney, Joanne L, Wong, F. Susan, Mallick, Caroline, Findly, R. Craig, Peng, Qingshuang, Craft, Joseph E, Owen, Michael J, Mayday, Adrian C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellular biology
Experimental and animal immunopathology. Animal models
Immunity (Disease)
Immunopathology
Medical sciences
Rodents
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Description
Summary:It is reported that in the absence of alphabeta T cells, B cells expand, differentiate and secrete copious amounts of antibodies of "T-dependent" isotypes. Antibodies are reactive towards self-antigens, as in patients with systemic lupus erythematosus.
ISSN:0028-0836
1476-4687
DOI:10.1038/369654a0