Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial

Ivermectin is being considered for mass drug administration for malaria due to its ability to kill mosquitoes feeding on recently treated individuals. However, standard, single doses of 150–200 μg/kg used for onchocerciasis and lymphatic filariasis have a short-lived mosquitocidal effect (

Saved in:
Bibliographic Details
Published in:The Lancet infectious diseases 2018-06, Vol.18 (6), p.615-626
Main Authors: Smit, Menno R, Ochomo, Eric O, Aljayyoussi, Ghaith, Kwambai, Titus K, Abong'o, Bernard O, Chen, Tao, Bousema, Teun, Slater, Hannah C, Waterhouse, David, Bayoh, Nabie M, Gimnig, John E, Samuels, Aaron M, Desai, Meghna R, Phillips-Howard, Penelope A, Kariuki, Simon K, Wang, Duolao, Ward, Steve A, ter Kuile, Feiko O
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Albuterol, Ipratropium Drug Combination
Anemia
Anopheles
Anopheles gambiae
Antimalarials - administration & dosage
Antimalarials - therapeutic use
Aquatic insects
Artemisinins - administration & dosage
Artemisinins - therapeutic use
Blood
Clinical trials
Culicidae
Dihydroartemisinin
Disease control
Dosage and administration
Double-Blind Method
Double-blind studies
Drug dosages
Drug Therapy, Combination
Effectiveness
Electrocardiography
FDA approval
Feeding
Female
Filariasis
Humans
Infectious diseases
Insecticides
Insecticides - administration & dosage
Insecticides - adverse effects
Insecticides - therapeutic use
Ivermectin
Ivermectin - administration & dosage
Ivermectin - adverse effects
Ivermectin - therapeutic use
Malaria
Malaria - drug therapy
Male
Middle Aged
Mortality
Mosquitoes
Onchocerciasis
Parasitic diseases
Patients
Plasmodium falciparum
Quinolines - administration & dosage
Quinolines - pharmacology
Randomization
Safety
Survival
Tropical diseases
Tuberculosis
Vector-borne diseases
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ivermectin is being considered for mass drug administration for malaria due to its ability to kill mosquitoes feeding on recently treated individuals. However, standard, single doses of 150–200 μg/kg used for onchocerciasis and lymphatic filariasis have a short-lived mosquitocidal effect (
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(18)30163-4