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Targeting cancer cells based on their phosphodiesterase 3A expression
An abstract of a study by Nazir et al on targeting cancer cells based on their phosphodiesterase 3A expression is presented. The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic...
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Published in: | European journal of cancer (1990) 2016-12, Vol.69, p.S21-S21 |
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container_title | European journal of cancer (1990) |
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creator | Nazir, M Nyberg, F Senkowski, W Larsson, R Fryknas, M |
description | An abstract of a study by Nazir et al on targeting cancer cells based on their phosphodiesterase 3A expression is presented. The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic substances as positive controls. Immunofluorescence Staining with primary antibody PDE3A and image analysis using Arrayscan. Results showed cell lines of various origins (i.e. melanoma, non-small cell lung cancer, colon carcinoma and cervical adenocarcinoma) striking in vitro sensitivity to Phosphodiesterase inhibitors. The PDE3 expressing cells were not more sensitive to standard drugs (doxorubicin, oxaliptatin and vincristine). |
doi_str_mv | 10.1016/S0959-8049(16)32643-0 |
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The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic substances as positive controls. Immunofluorescence Staining with primary antibody PDE3A and image analysis using Arrayscan. Results showed cell lines of various origins (i.e. melanoma, non-small cell lung cancer, colon carcinoma and cervical adenocarcinoma) striking in vitro sensitivity to Phosphodiesterase inhibitors. 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The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic substances as positive controls. Immunofluorescence Staining with primary antibody PDE3A and image analysis using Arrayscan. Results showed cell lines of various origins (i.e. melanoma, non-small cell lung cancer, colon carcinoma and cervical adenocarcinoma) striking in vitro sensitivity to Phosphodiesterase inhibitors. The PDE3 expressing cells were not more sensitive to standard drugs (doxorubicin, oxaliptatin and vincristine).</description><subject>Adenocarcinoma</subject><subject>Cancer</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Cytotoxicity</subject><subject>Doxorubicin</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Image analysis</subject><subject>Image processing</subject><subject>Immunofluorescence</subject><subject>Inhibitors</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Melanoma</subject><subject>Non-small cell lung carcinoma</subject><subject>Phosphodiesterase</subject><subject>Phosphodiesterase inhibitors</subject><subject>Small cell lung carcinoma</subject><subject>Toxicity</subject><subject>Vincristine</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNo9UE1LAzEQDaJgrf4EIeBFD6uTZHezuQil1A8oeLCeQzY726auu2vSiv33pl3pYXgM8-a9mUfINYN7Bix_eAeVqaSAVN2y_E7wPBUJnJARK6RKoMj4KRkdKefkIoQ1AMgihRGZLYxf4sa1S2pNa9FTi00TaGkCVrRr6WaFztN-1YVYlcOwQR9nVEwo_vYeQ3Bde0nOatMEvPrHMfl4mi2mL8n87fl1OpknlnElEo61NBVWBYpM2pIVxpacI1dSiBRqropaQSXzyJJQyggZ1BVXyqY1cMzFmNwMur3vvrfxFr3utr6NlpqDkGkKPBWRlQ0s67sQPNa69-7L-J1moPeJ6UNieh-Hjt0hMQ1x73HYw_jCj0OvbeNaZ03ziTsMRyumA9cwiOw1WH5QAPEHzQBzOA</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Nazir, M</creator><creator>Nyberg, F</creator><creator>Senkowski, W</creator><creator>Larsson, R</creator><creator>Fryknas, M</creator><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20161201</creationdate><title>Targeting cancer cells based on their phosphodiesterase 3A expression</title><author>Nazir, M ; Nyberg, F ; Senkowski, W ; Larsson, R ; Fryknas, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1293-2ef7aded8e357cb18acb22e2973340f298f90d76f7a70b7f7a50fd299c4f02e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma</topic><topic>Cancer</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Cytotoxicity</topic><topic>Doxorubicin</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Image analysis</topic><topic>Image processing</topic><topic>Immunofluorescence</topic><topic>Inhibitors</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Melanoma</topic><topic>Non-small cell lung carcinoma</topic><topic>Phosphodiesterase</topic><topic>Phosphodiesterase inhibitors</topic><topic>Small cell lung carcinoma</topic><topic>Toxicity</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nazir, M</creatorcontrib><creatorcontrib>Nyberg, F</creatorcontrib><creatorcontrib>Senkowski, W</creatorcontrib><creatorcontrib>Larsson, R</creatorcontrib><creatorcontrib>Fryknas, M</creatorcontrib><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nazir, M</au><au>Nyberg, F</au><au>Senkowski, W</au><au>Larsson, R</au><au>Fryknas, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting cancer cells based on their phosphodiesterase 3A expression</atitle><jtitle>European journal of cancer (1990)</jtitle><date>2016-12-01</date><risdate>2016</risdate><volume>69</volume><spage>S21</spage><epage>S21</epage><pages>S21-S21</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>An abstract of a study by Nazir et al on targeting cancer cells based on their phosphodiesterase 3A expression is presented. 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subjects | Adenocarcinoma Cancer Cervical cancer Cervix Colon Colon cancer Colorectal cancer Cytotoxicity Doxorubicin Hematology, Oncology and Palliative Medicine Image analysis Image processing Immunofluorescence Inhibitors Lung cancer Lung carcinoma Melanoma Non-small cell lung carcinoma Phosphodiesterase Phosphodiesterase inhibitors Small cell lung carcinoma Toxicity Vincristine |
title | Targeting cancer cells based on their phosphodiesterase 3A expression |
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