Targeting cancer cells based on their phosphodiesterase 3A expression

An abstract of a study by Nazir et al on targeting cancer cells based on their phosphodiesterase 3A expression is presented. The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic...

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Bibliographic Details
Published in:European journal of cancer (1990) 2016-12, Vol.69, p.S21-S21
Main Authors: Nazir, M, Nyberg, F, Senkowski, W, Larsson, R, Fryknas, M
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer
Cervical cancer
Cervix
Colon
Colon cancer
Colorectal cancer
Cytotoxicity
Doxorubicin
Hematology, Oncology and Palliative Medicine
Image analysis
Image processing
Immunofluorescence
Inhibitors
Lung cancer
Lung carcinoma
Melanoma
Non-small cell lung carcinoma
Phosphodiesterase
Phosphodiesterase inhibitors
Small cell lung carcinoma
Toxicity
Vincristine
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Summary:An abstract of a study by Nazir et al on targeting cancer cells based on their phosphodiesterase 3A expression is presented. The study used Fluorometric Microculture Cytotoxicity Assay for measurement of the cytotoxicity, and PDE-inhibitors including zardaverine, quazinone, enoximone, and cytotoxic substances as positive controls. Immunofluorescence Staining with primary antibody PDE3A and image analysis using Arrayscan. Results showed cell lines of various origins (i.e. melanoma, non-small cell lung cancer, colon carcinoma and cervical adenocarcinoma) striking in vitro sensitivity to Phosphodiesterase inhibitors. The PDE3 expressing cells were not more sensitive to standard drugs (doxorubicin, oxaliptatin and vincristine).
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(16)32643-0