Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar neurons is required. Here, we report that subplate neurons, one of the first neuron types born in the neocortex, ma...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2018-04, Vol.360 (6386), p.313-317
Main Authors: Ohtaka-Maruyama, Chiaki, Okamoto, Mayumi, Endo, Kentaro, Oshima, Minori, Kaneko, Noe, Yura, Kei, Okado, Haruo, Miyata, Takaki, Maeda, Nobuaki
Format: Article
Language:English
Subjects:
Axons
Brain
Cortex
Embryos
Glutamatergic transmission
Glutamic acid receptors
Locomotion
Migrants
Migration
N-Methyl-D-aspartic acid receptors
Neuroimaging
Neurons
Phenotypes
Synapses
Synaptic transmission
Synaptogenesis
Ventricle
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Summary:The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar neurons is required. Here, we report that subplate neurons, one of the first neuron types born in the neocortex, manage the multipolar-to-bipolar transition of migrating neurons. By histochemical, imaging, and microarray analyses on the mouse embryonic cortex, we found that subplate neurons extend neurites toward the ventricular side of the subplate and form transient glutamatergic synapses on the multipolar neurons just below the subplate. NMDAR ( -methyl-d-aspartate receptor)-mediated synaptic transmission from subplate neurons to multipolar neurons induces the multipolar-to-bipolar transition, leading to a change in migration mode from slow multipolar migration to faster radial glial-guided locomotion. Our data suggested that transient synapses formed on early immature neurons regulate radial migration.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aar2866