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Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer
PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a U...
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| Published in: | Journal of assisted reproduction and genetics 2018-03, Vol.35 (3), p.425-429 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Hatoum, I Bellon, L Swierkowski, N Ouazana, M Bouba, S Fathallah, K Paillusson, B Bailly, M Boitrelle, F Alter, L Bergère, M Selva, J Wainer, R |
| description | PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles. Live birth rate and early pregnancy loss rates were retrospectively compared.In artificial protocols, oral or vaginal administration of oestradiol 2 mg two or three times a day was followed by vaginal supplementation with progesterone 200 mg two or three times a day. In stimulated protocols, recombinant follicle-stimulating hormone was administered from day 4 onward. Vaginal ultrasound was used for endometrial and ovarian monitoring. A pregnancy test was performed 14 days after FET. If it was positive, oestradiol and progesterone were administered up until the 12th week of gestation in artificial cycles. We defined early pregnancy losses as biochemical pregnancies (preclinical losses) and miscarriages.ResultsData on 865 artificial cycles (45% of the total) and 1061 stimulated cycles (55%) were collected. Early pregnancy loss rate was significantly lower for stimulated cycles (34.2%) than for artificial cycles (56.9%), and the live birth rate was significantly higher for stimulated cycles (59.7%) than for artificial cycles (29.1%).ConclusionIn frozen embryo transfer, artificial cycles were associated with more early pregnancy loss and lower live birth rate than stimulated cycles. |
| doi_str_mv | 10.1007/s10815-017-1078-0 |
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| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2026316803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2026316803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c204t-7ae0ff672b528ce2a076d00cc00ccace71c83b98494e4ee0872b2996eaadda203</originalsourceid><addsrcrecordid>eNotTstOBCEQJEYT19UP8EbiGW1gZmCOZn0mm3jR84aBHmWzCyMwJvr1stFDpypdXVVNyCWHaw6gbjIHzVsGXDEOSjM4IgveKsmUlHBcObR12XT6lJzlvAWAXgu5INOdz5NJvnjM1AeacErRzbb4L6RxLjbuq2Csjcn58E5LpOUDKQZXhZK82dGpekwyxcdQeSzRxt0hakzxBwPF_ZC-qyuZkEdM5-RkNLuMF_-4JG8P96-rJ7Z-eXxe3a6ZFdAUpgzCOHZKDK3QFoUB1TkAaw9jLCputRx63fQNNoig66Xo-w6Ncc4IkEty9ZdbX_qcMZfNNs4p1MqNANFJ3mmQ8hf-lF98</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2026316803</pqid></control><display><type>article</type><title>Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer</title><source>Springer Link</source><source>PubMed Central</source><creator>Hatoum, I ; Bellon, L ; Swierkowski, N ; Ouazana, M ; Bouba, S ; Fathallah, K ; Paillusson, B ; Bailly, M ; Boitrelle, F ; Alter, L ; Bergère, M ; Selva, J ; Wainer, R</creator><creatorcontrib>Hatoum, I ; Bellon, L ; Swierkowski, N ; Ouazana, M ; Bouba, S ; Fathallah, K ; Paillusson, B ; Bailly, M ; Boitrelle, F ; Alter, L ; Bergère, M ; Selva, J ; Wainer, R</creatorcontrib><description>PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles. Live birth rate and early pregnancy loss rates were retrospectively compared.In artificial protocols, oral or vaginal administration of oestradiol 2 mg two or three times a day was followed by vaginal supplementation with progesterone 200 mg two or three times a day. In stimulated protocols, recombinant follicle-stimulating hormone was administered from day 4 onward. Vaginal ultrasound was used for endometrial and ovarian monitoring. A pregnancy test was performed 14 days after FET. If it was positive, oestradiol and progesterone were administered up until the 12th week of gestation in artificial cycles. We defined early pregnancy losses as biochemical pregnancies (preclinical losses) and miscarriages.ResultsData on 865 artificial cycles (45% of the total) and 1061 stimulated cycles (55%) were collected. Early pregnancy loss rate was significantly lower for stimulated cycles (34.2%) than for artificial cycles (56.9%), and the live birth rate was significantly higher for stimulated cycles (59.7%) than for artificial cycles (29.1%).ConclusionIn frozen embryo transfer, artificial cycles were associated with more early pregnancy loss and lower live birth rate than stimulated cycles.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-017-1078-0</identifier><language>eng</language><publisher>New York: Springer Nature B.V</publisher><subject>Birth rate ; Clinical outcomes ; Embryo transfer ; Embryos ; Endometrium ; Fertility ; Follicle-stimulating hormone ; Gestation ; In vitro fertilization ; Pregnancy ; Progesterone ; Ultrasound</subject><ispartof>Journal of assisted reproduction and genetics, 2018-03, Vol.35 (3), p.425-429</ispartof><rights>Journal of Assisted Reproduction and Genetics is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c204t-7ae0ff672b528ce2a076d00cc00ccace71c83b98494e4ee0872b2996eaadda203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Hatoum, I</creatorcontrib><creatorcontrib>Bellon, L</creatorcontrib><creatorcontrib>Swierkowski, N</creatorcontrib><creatorcontrib>Ouazana, M</creatorcontrib><creatorcontrib>Bouba, S</creatorcontrib><creatorcontrib>Fathallah, K</creatorcontrib><creatorcontrib>Paillusson, B</creatorcontrib><creatorcontrib>Bailly, M</creatorcontrib><creatorcontrib>Boitrelle, F</creatorcontrib><creatorcontrib>Alter, L</creatorcontrib><creatorcontrib>Bergère, M</creatorcontrib><creatorcontrib>Selva, J</creatorcontrib><creatorcontrib>Wainer, R</creatorcontrib><title>Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer</title><title>Journal of assisted reproduction and genetics</title><description>PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles. Live birth rate and early pregnancy loss rates were retrospectively compared.In artificial protocols, oral or vaginal administration of oestradiol 2 mg two or three times a day was followed by vaginal supplementation with progesterone 200 mg two or three times a day. In stimulated protocols, recombinant follicle-stimulating hormone was administered from day 4 onward. Vaginal ultrasound was used for endometrial and ovarian monitoring. A pregnancy test was performed 14 days after FET. If it was positive, oestradiol and progesterone were administered up until the 12th week of gestation in artificial cycles. We defined early pregnancy losses as biochemical pregnancies (preclinical losses) and miscarriages.ResultsData on 865 artificial cycles (45% of the total) and 1061 stimulated cycles (55%) were collected. Early pregnancy loss rate was significantly lower for stimulated cycles (34.2%) than for artificial cycles (56.9%), and the live birth rate was significantly higher for stimulated cycles (59.7%) than for artificial cycles (29.1%).ConclusionIn frozen embryo transfer, artificial cycles were associated with more early pregnancy loss and lower live birth rate than stimulated cycles.</description><subject>Birth rate</subject><subject>Clinical outcomes</subject><subject>Embryo transfer</subject><subject>Embryos</subject><subject>Endometrium</subject><subject>Fertility</subject><subject>Follicle-stimulating hormone</subject><subject>Gestation</subject><subject>In vitro fertilization</subject><subject>Pregnancy</subject><subject>Progesterone</subject><subject>Ultrasound</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNotTstOBCEQJEYT19UP8EbiGW1gZmCOZn0mm3jR84aBHmWzCyMwJvr1stFDpypdXVVNyCWHaw6gbjIHzVsGXDEOSjM4IgveKsmUlHBcObR12XT6lJzlvAWAXgu5INOdz5NJvnjM1AeacErRzbb4L6RxLjbuq2Csjcn58E5LpOUDKQZXhZK82dGpekwyxcdQeSzRxt0hakzxBwPF_ZC-qyuZkEdM5-RkNLuMF_-4JG8P96-rJ7Z-eXxe3a6ZFdAUpgzCOHZKDK3QFoUB1TkAaw9jLCputRx63fQNNoig66Xo-w6Ncc4IkEty9ZdbX_qcMZfNNs4p1MqNANFJ3mmQ8hf-lF98</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Hatoum, I</creator><creator>Bellon, L</creator><creator>Swierkowski, N</creator><creator>Ouazana, M</creator><creator>Bouba, S</creator><creator>Fathallah, K</creator><creator>Paillusson, B</creator><creator>Bailly, M</creator><creator>Boitrelle, F</creator><creator>Alter, L</creator><creator>Bergère, M</creator><creator>Selva, J</creator><creator>Wainer, R</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope></search><sort><creationdate>20180301</creationdate><title>Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer</title><author>Hatoum, I ; Bellon, L ; Swierkowski, N ; Ouazana, M ; Bouba, S ; Fathallah, K ; Paillusson, B ; Bailly, M ; Boitrelle, F ; Alter, L ; Bergère, M ; Selva, J ; Wainer, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c204t-7ae0ff672b528ce2a076d00cc00ccace71c83b98494e4ee0872b2996eaadda203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Birth rate</topic><topic>Clinical outcomes</topic><topic>Embryo transfer</topic><topic>Embryos</topic><topic>Endometrium</topic><topic>Fertility</topic><topic>Follicle-stimulating hormone</topic><topic>Gestation</topic><topic>In vitro fertilization</topic><topic>Pregnancy</topic><topic>Progesterone</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatoum, I</creatorcontrib><creatorcontrib>Bellon, L</creatorcontrib><creatorcontrib>Swierkowski, N</creatorcontrib><creatorcontrib>Ouazana, M</creatorcontrib><creatorcontrib>Bouba, S</creatorcontrib><creatorcontrib>Fathallah, K</creatorcontrib><creatorcontrib>Paillusson, B</creatorcontrib><creatorcontrib>Bailly, M</creatorcontrib><creatorcontrib>Boitrelle, F</creatorcontrib><creatorcontrib>Alter, L</creatorcontrib><creatorcontrib>Bergère, M</creatorcontrib><creatorcontrib>Selva, J</creatorcontrib><creatorcontrib>Wainer, R</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatoum, I</au><au>Bellon, L</au><au>Swierkowski, N</au><au>Ouazana, M</au><au>Bouba, S</au><au>Fathallah, K</au><au>Paillusson, B</au><au>Bailly, M</au><au>Boitrelle, F</au><au>Alter, L</au><au>Bergère, M</au><au>Selva, J</au><au>Wainer, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>35</volume><issue>3</issue><spage>425</spage><epage>429</epage><pages>425-429</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles. Live birth rate and early pregnancy loss rates were retrospectively compared.In artificial protocols, oral or vaginal administration of oestradiol 2 mg two or three times a day was followed by vaginal supplementation with progesterone 200 mg two or three times a day. In stimulated protocols, recombinant follicle-stimulating hormone was administered from day 4 onward. Vaginal ultrasound was used for endometrial and ovarian monitoring. A pregnancy test was performed 14 days after FET. If it was positive, oestradiol and progesterone were administered up until the 12th week of gestation in artificial cycles. We defined early pregnancy losses as biochemical pregnancies (preclinical losses) and miscarriages.ResultsData on 865 artificial cycles (45% of the total) and 1061 stimulated cycles (55%) were collected. Early pregnancy loss rate was significantly lower for stimulated cycles (34.2%) than for artificial cycles (56.9%), and the live birth rate was significantly higher for stimulated cycles (59.7%) than for artificial cycles (29.1%).ConclusionIn frozen embryo transfer, artificial cycles were associated with more early pregnancy loss and lower live birth rate than stimulated cycles.</abstract><cop>New York</cop><pub>Springer Nature B.V</pub><doi>10.1007/s10815-017-1078-0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Birth rate Clinical outcomes Embryo transfer Embryos Endometrium Fertility Follicle-stimulating hormone Gestation In vitro fertilization Pregnancy Progesterone Ultrasound |
| title | Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer |
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