Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer

PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a U...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2018-03, Vol.35 (3), p.425-429
Main Authors: Hatoum, I, Bellon, L, Swierkowski, N, Ouazana, M, Bouba, S, Fathallah, K, Paillusson, B, Bailly, M, Boitrelle, F, Alter, L, Bergère, M, Selva, J, Wainer, R
Format: Article
Language:English
Subjects:
Birth rate
Clinical outcomes
Embryo transfer
Embryos
Endometrium
Fertility
Follicle-stimulating hormone
Gestation
In vitro fertilization
Pregnancy
Progesterone
Ultrasound
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Summary:PurposeThe purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles.MethodsWe performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles. Live birth rate and early pregnancy loss rates were retrospectively compared.In artificial protocols, oral or vaginal administration of oestradiol 2 mg two or three times a day was followed by vaginal supplementation with progesterone 200 mg two or three times a day. In stimulated protocols, recombinant follicle-stimulating hormone was administered from day 4 onward. Vaginal ultrasound was used for endometrial and ovarian monitoring. A pregnancy test was performed 14 days after FET. If it was positive, oestradiol and progesterone were administered up until the 12th week of gestation in artificial cycles. We defined early pregnancy losses as biochemical pregnancies (preclinical losses) and miscarriages.ResultsData on 865 artificial cycles (45% of the total) and 1061 stimulated cycles (55%) were collected. Early pregnancy loss rate was significantly lower for stimulated cycles (34.2%) than for artificial cycles (56.9%), and the live birth rate was significantly higher for stimulated cycles (59.7%) than for artificial cycles (29.1%).ConclusionIn frozen embryo transfer, artificial cycles were associated with more early pregnancy loss and lower live birth rate than stimulated cycles.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-017-1078-0