Polycationic Synergistic Antibacterial Agents with Multiple Functional Components for Efficient Anti‐Infective Therapy

Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug‐resistant bacteria. In this work, eosin Y (EY)‐based antibacterial polycations (EY‐QEGEDR, R = CH3 or C6H13) with versatile types of functional components including quaternary ammonium, photos...

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Bibliographic Details
Published in:Advanced functional materials 2018-04, Vol.28 (14), p.n/a
Main Authors: Zhu, Yiwen, Xu, Chen, Zhang, Na, Ding, Xiaokang, Yu, Bingran, Xu, Fu‐Jian
Format: Article
Language:English
Subjects:
Antibacterial materials
Antifouling coatings
anti‐infective coating
Bacteria
Biocompatibility
Biomedical materials
Chemical synthesis
E coli
Glass substrates
Hydroxyl groups
Light irradiation
Materials science
Photodynamic therapy
Polymer coatings
quaternary ammonium
synergistic antibacterials
Toxicity
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Summary:Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug‐resistant bacteria. In this work, eosin Y (EY)‐based antibacterial polycations (EY‐QEGEDR, R = CH3 or C6H13) with versatile types of functional components including quaternary ammonium, photosensitizer, primary amine, and hydroxyl species are readily synthesized based on simple ring‐opening reactions. In the presence of light irradiation, such antibacterial polymers exhibit high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus. In particular, EY‐QEGEDR elicits a remarkable synergistic antibacterial activity owing to the combined photodynamic and quaternary ammonium antibacterial effects. Due to its rich primary amine groups, EY‐QEGEDR also can be readily coated on different substrates, such as glass slides and nonwoven fabrics via an adhesive layer of polydopamine. The resultant surface coating of EY‐QEGEDCH3 (s‐EY‐QEGEDCH3) produces excellent in vitro antibacterial efficacy. The plentiful hydroxyl groups impart s‐EY‐QEGEDCH3 with potential antifouling capability against dead bacteria. The antibacterial polymer coatings also demonstrate low cytotoxicity and good hemocompatibility. More importantly, s‐EY‐QEGEDCH3 significantly enhances in vivo therapeutic effects on an infected rat model. The present work provides an efficient strategy for the rational design of high‐performance antibacterial materials to fight biomedical device‐associated infections. Polycationic synergistic antibacterial agents with versatile functional components including quaternary ammonium, photosensitizer, primary amine, and hydroxyl species are proposed for effective biomedical applications.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201706709