Recent Advances in Pd‐Catalyzed Cross‐Coupling Reaction in Ionic Liquids

Ionic liquids (ILs) can behave as green solvents in comparison with conventional organic solvents, but more often they also act as ligands, co‐catalysts, and stabilizing agents both for metal active species and for intermediates of catalytic systems. In this review we have mainly summarized the rece...

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Bibliographic Details
Published in:European journal of organic chemistry 2018-03, Vol.2018 (11), p.1284-1306
Main Authors: Li, Jianxiao, Yang, Shaorong, Wu, Wanqing, Jiang, Huanfeng
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Catalysis
Chemical reactions
Coupling (molecular)
Cross‐coupling
Green solvents
Ionic liquids
Ions
Organic chemistry
Palladium
Reaction mechanisms
Solvents
Synthetic methods
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Summary:Ionic liquids (ILs) can behave as green solvents in comparison with conventional organic solvents, but more often they also act as ligands, co‐catalysts, and stabilizing agents both for metal active species and for intermediates of catalytic systems. In this review we have mainly summarized the recent achievements (2013 to the present) in Pd‐catalyzed cross‐coupling in ILs for the assembly of structurally diverse and highly functionalized organic molecules, with the focus on cascade reactions triggered by nucleopalladation, Suzuki coupling, Sonogashira coupling, allylic functionalization, and other types of coupling. The reaction conditions, regio‐ and stereoselectivities, and mechanisms are summarized in detail. We also highlight important and representative examples and synthetic applications of these coupling reactions. We hope that this review will result in further focused research to widen the comprehension and application of ILs in the future. This microreview briefly summarizes the recent developments in Pd‐catalyzed cross‐coupling in ionic liquids. In addition, we also highlight the synthetic methods, catalytic systems, and mechanisms of selected coupling reactions.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201701509