Biodegradable Cell-Seeded Collagen Based Polymer Scaffolds for Wound Healing and Skin Reconstruction

In the present study a collagen-glycosaminoglycans scaffold, following chemical modifications, was prepared as an analog of the extracellular matrix (ECM) by a freeze drying method. Appropriate tests related to its use for wound healing (evaluation of the structure by scanning electron microscopy, s...

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Bibliographic Details
Published in:Journal of macromolecular science. Physics 2018-02, Vol.57 (2), p.100-109
Main Authors: Ansari, Mojtaba, Kordestani, Soheila Salahshoor, Nazralizadeh, Sanaz, Eslami, Hossein
Format: Article
Language:English
Subjects:
Amniotic fluid
Amniotic fluid-derived stem (AFS) cells
Biodegradability
Biodegradation
Cell culture
Collagen
collagen-glycosaminoglycan scaffolds
Electron microscopy
Extracellular matrix
Fourier transforms
Freeze drying
Glycosaminoglycans
Infrared spectroscopy
Scaffolds
Scanning electron microscopy
Scanning transmission electron microscopy
Skin
Test procedures
wound dressings
Wound healing
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Summary:In the present study a collagen-glycosaminoglycans scaffold, following chemical modifications, was prepared as an analog of the extracellular matrix (ECM) by a freeze drying method. Appropriate tests related to its use for wound healing (evaluation of the structure by scanning electron microscopy, swelling properties, biodegradability properties, Fourier transform infrared spectroscopy and cell culture) were done on the scaffolds. Amniotic fluid-derived stem (AFS) cell seeded scaffolds were shown to be potentially useful for wound healing.
ISSN:0022-2348
1525-609X
DOI:10.1080/00222348.2018.1435617