Presence of an Inducible HIV-1 Latent Reservoir during Highly Active Antiretroviral Therapy

Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4+ T...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-11, Vol.94 (24), p.13193-13197
Main Authors: Chun, Tae-Wook, Stuyver, Lieven, Mizell, Stephanie B., Ehler, Linda A., Jo Ann M. Mican, Baseler, Michael, Lloyd, Alun L., Nowak, Martin A., Fauci, Anthony S.
Format: Article
Language:English
Subjects:
AIDS/HIV
Anti-HIV Agents - therapeutic use
Biological Sciences
Blood plasma
CD4-Positive T-Lymphocytes - virology
Deoxyribonucleic acid
DNA
DNA, Viral
Drug therapy
Genomics
Giant Cells
Highly active antiretroviral therapy
HIV
HIV 1
HIV Infections - drug therapy
HIV Infections - virology
HIV-1 - genetics
HIV-1 - isolation & purification
HIV-1 - physiology
Human immunodeficiency virus
Humans
Medical research
Plasma
Polymerase chain reaction
T lymphocytes
Viremia
Virus Latency
Virus Replication
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4+ T cells and what role these cells play in the persistence of HIV-1 infection in individuals receiving such treatment. The present study demonstrates that highly purified CD4+ T cells from 13 of 13 patients receiving HAART with an average treatment time of 10 months and with undetectable (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.24.13193