Delivery of a stringent dimerizer-regulated gene experssion system in a single retroviral vector

Small molecule-regulated transcription has broad utility and would benefit from an easily delivered self-contained regulatory cassette capable of robust, tightly controlled target gene expression. We describe the delivery of a modified dimerizer-regulated gene expression system to cells on a single...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-11, Vol.97 (24), p.13221
Main Authors: Pollock, Roy, Issner, Robbyn, Zoller, Karen, Sridaran Natesan
Format: Article
Language:English
Subjects:
Genetics
Proteins
Viruses
Online Access:Get full text
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Summary:Small molecule-regulated transcription has broad utility and would benefit from an easily delivered self-contained regulatory cassette capable of robust, tightly controlled target gene expression. We describe the delivery of a modified dimerizer-regulated gene expression system to cells on a single retrovirus.
ISSN:0027-8424
1091-6490