Adipose‐derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers

Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas...

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Bibliographic Details
Published in:Environmental toxicology 2018-04, Vol.33 (4), p.508-513
Main Authors: Chen, Tung‐Sheng, Kuo, Chia‐Hua, Battsengel, Sarnai, Pan, Lung‐Fa, Day, Cecilia Hsuan, Shen, Chia‐Yao, Chung, Li‐Chin, Padma, V. Vijaya, Yao, Chen‐Kai, Lin, Yueh‐Min, Huang, Chih‐Yang
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cardiomyocytes
Cardiomyopathy
Complications
Damage
endotoxin
Endotoxins
Fibrosis
Gum disease
Heart
Heart diseases
Hemoglobin
Herbal medicine
Hypertrophy
IGF1
Insulin-like growth factor I
Lipopolysaccharides
MAP kinase
Periodontal disease
Periodontics
Signaling
stem cell
Stem cells
Viability
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Summary:Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg‐LPS). From the experimental results we find that Pg‐LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg‐LPS damaged cardiomyocytes co‐cultured with adipose‐derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg‐LPS induced protective effect on cardiomyocyte damage.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.22536