In vivo Positron-Emission Tomography Imaging of Progression and Transformation in a Mouse Model of Mammary Neoplasia

Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy- D-glucose t...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (31), p.11438-11443
Main Authors: Abbey, Craig K., Borowsky, Alexander D., McGoldrick, Erik T., Gregg, Jeffrey P., Maglione, Jeannie E., Cardiff, Robert D., Cherry, Simon R., Phelps, Michael E.
Format: Article
Language:English
Subjects:
Adipose tissues
Animals
Biological Sciences
Disease models
Disease Models, Animal
Disease Progression
Fluorodeoxyglucose F18
Histology
Imaging
Lesions
Longitudinal Studies
Mammary Glands, Animal - diagnostic imaging
Mammary Glands, Animal - pathology
Mammary Neoplasms, Animal - diagnostic imaging
Mammary Neoplasms, Animal - pathology
Mice
Positron emission tomography
Positrons
Rodents
Scientific imaging
Tissue transplantation
Tomography
Tomography, Emission-Computed - methods
Transplantation
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy- D-glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0404396101