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Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study
Aim To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans. Materials and methods In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period....
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| Published in: | Diabetes, obesity & metabolism obesity & metabolism, 2018-04, Vol.20 (4), p.840-848 |
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| container_issue | 4 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Thuzar, Moe Law, Weikiat Phillip Ratnasingam, Jeyakantha Jang, Christina Dimeski, Goce Ho, Ken K. Y. |
| description | Aim
To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans.
Materials and methods
In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period. BAT function was assessed in response to cooling (19°C) and to a standardized meal, by measuring fluoro‐deoxyglucose (FDG) uptake using positron emission tomography‐computed tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry.
Results
During cooling, prednisolone significantly reduced BAT FDG uptake (standardized uptake value, SUVmax, 6.1 ± 2.2 vs 3.7 ± 1.2; P |
| doi_str_mv | 10.1111/dom.13157 |
| format | article |
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To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans.
Materials and methods
In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period. BAT function was assessed in response to cooling (19°C) and to a standardized meal, by measuring fluoro‐deoxyglucose (FDG) uptake using positron emission tomography‐computed tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry.
Results
During cooling, prednisolone significantly reduced BAT FDG uptake (standardized uptake value, SUVmax, 6.1 ± 2.2 vs 3.7 ± 1.2; P < .05) and SCL temperature (−0.45 ± 0.1 vs −1.0 ± 0.1°C; P < .01) compared to placebo. Postprandially, prednisolone significantly blunted the rise in SCL temperature (+0.2 ± 0.1 vs −0.3 ± 0.1°C; P < .05), enhanced energy production (+221 ± 17 vs +283 ± 27 kcal/d; P < .01) and lipid synthesis (+16.3 ± 3.2 vs +23.6 ± 4.9 mg/min; P < .05). The prednisolone‐induced reduction in SCL temperature significantly correlated with the reduction in FDG uptake (r = 0.65, P < .05), while the increase in energy production significantly correlated with the increase in lipogenesis (r = 0.6, P < .05).
Conclusion
Prolonged exposure to glucocorticoid suppresses the function of human BAT. The enhancement of energy production and lipogenesis in the face of reduced dissipation of energy as heat suggests that glucocorticoids channel energy towards fat storage after nutrient intake. This is a novel mechanism of glucocorticoid‐induced obesity.]]></description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.13157</identifier><identifier>PMID: 29119718</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - physiology ; Adolescent ; Adult ; brown adipose tissue ; brown fat ; Calorimetry ; Clavicle ; Cold Temperature ; Computed tomography ; Cross-Over Studies ; Deoxyglucose ; Double-Blind Method ; Double-blind studies ; Down-Regulation - drug effects ; Energy ; Energy metabolism ; Energy Metabolism - drug effects ; Female ; Glucocorticoids ; Glucocorticoids - administration & dosage ; Glucocorticoids - pharmacology ; Humans ; lipid ; Lipogenesis ; Male ; metabolism ; Obesity ; Placebos ; Positron emission tomography ; Prednisolone ; Prednisolone - administration & dosage ; Prednisolone - pharmacology ; regulation ; Skin ; Skin Temperature - drug effects ; Temperature ; Temperature effects ; thermogenesis ; Thermogenesis - drug effects ; Thermography ; Tomography ; Young Adult</subject><ispartof>Diabetes, obesity & metabolism, 2018-04, Vol.20 (4), p.840-848</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>2018 John Wiley & Sons Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3207-9fb47f87f938708c55fedb1889a93558f348b1ff8893f407bfe28857682fd5a63</citedby><cites>FETCH-LOGICAL-c3207-9fb47f87f938708c55fedb1889a93558f348b1ff8893f407bfe28857682fd5a63</cites><orcidid>0000-0002-2508-9588</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.13157$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.13157$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29119718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thuzar, Moe</creatorcontrib><creatorcontrib>Law, Weikiat Phillip</creatorcontrib><creatorcontrib>Ratnasingam, Jeyakantha</creatorcontrib><creatorcontrib>Jang, Christina</creatorcontrib><creatorcontrib>Dimeski, Goce</creatorcontrib><creatorcontrib>Ho, Ken K. Y.</creatorcontrib><title>Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description><![CDATA[Aim
To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans.
Materials and methods
In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period. BAT function was assessed in response to cooling (19°C) and to a standardized meal, by measuring fluoro‐deoxyglucose (FDG) uptake using positron emission tomography‐computed tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry.
Results
During cooling, prednisolone significantly reduced BAT FDG uptake (standardized uptake value, SUVmax, 6.1 ± 2.2 vs 3.7 ± 1.2; P < .05) and SCL temperature (−0.45 ± 0.1 vs −1.0 ± 0.1°C; P < .01) compared to placebo. Postprandially, prednisolone significantly blunted the rise in SCL temperature (+0.2 ± 0.1 vs −0.3 ± 0.1°C; P < .05), enhanced energy production (+221 ± 17 vs +283 ± 27 kcal/d; P < .01) and lipid synthesis (+16.3 ± 3.2 vs +23.6 ± 4.9 mg/min; P < .05). The prednisolone‐induced reduction in SCL temperature significantly correlated with the reduction in FDG uptake (r = 0.65, P < .05), while the increase in energy production significantly correlated with the increase in lipogenesis (r = 0.6, P < .05).
Conclusion
Prolonged exposure to glucocorticoid suppresses the function of human BAT. The enhancement of energy production and lipogenesis in the face of reduced dissipation of energy as heat suggests that glucocorticoids channel energy towards fat storage after nutrient intake. This is a novel mechanism of glucocorticoid‐induced obesity.]]></description><subject>Adipose tissue</subject><subject>Adipose tissue (brown)</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>brown adipose tissue</subject><subject>brown fat</subject><subject>Calorimetry</subject><subject>Clavicle</subject><subject>Cold Temperature</subject><subject>Computed tomography</subject><subject>Cross-Over Studies</subject><subject>Deoxyglucose</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Down-Regulation - drug effects</subject><subject>Energy</subject><subject>Energy metabolism</subject><subject>Energy Metabolism - drug effects</subject><subject>Female</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - pharmacology</subject><subject>Humans</subject><subject>lipid</subject><subject>Lipogenesis</subject><subject>Male</subject><subject>metabolism</subject><subject>Obesity</subject><subject>Placebos</subject><subject>Positron emission tomography</subject><subject>Prednisolone</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - pharmacology</subject><subject>regulation</subject><subject>Skin</subject><subject>Skin Temperature - drug effects</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>thermogenesis</subject><subject>Thermogenesis - drug effects</subject><subject>Thermography</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kEtOwzAQhi0EoqWw4ALIEisWaf1IGoddVaAgFXUD6yh-CVdJHOxYVXccgTNyEkxb2DGbGVuf_hl9AFxiNMaxJtI2Y0xxlh-BIU6nNMGUTI93M0lYgcgAnHm_RgillOWnYEAKjIscsyFoFnUQVljXG2GN9NCHrnPKe8id3bSwkqazXsHeeB8U1KEVvbEtNC18C03V-ls4g9IGXquvj09em1bCrq6E4ja-hW17Z-taSej7ILfn4ERXtVcXhz4Crw_3L_PHZLlaPM1ny0RQgvKk0DzNNct1Ec9FTGSZVpJjxoqqoFnGNE0Zx1rHD6pTlHOtCGNZPmVEy6ya0hG43ud2zr4H5ftybYNr48qSIEwYxdFFpG72lHDWe6d02TnTVG5bYlT-iC2j2HInNrJXh8TAGyX_yF-TEZjsgY2p1fb_pPJu9byP_AbpwIVG</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Thuzar, Moe</creator><creator>Law, Weikiat Phillip</creator><creator>Ratnasingam, Jeyakantha</creator><creator>Jang, Christina</creator><creator>Dimeski, Goce</creator><creator>Ho, Ken K. Y.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-2508-9588</orcidid></search><sort><creationdate>201804</creationdate><title>Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study</title><author>Thuzar, Moe ; Law, Weikiat Phillip ; Ratnasingam, Jeyakantha ; Jang, Christina ; Dimeski, Goce ; Ho, Ken K. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3207-9fb47f87f938708c55fedb1889a93558f348b1ff8893f407bfe28857682fd5a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adipose tissue (brown)</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>brown adipose tissue</topic><topic>brown fat</topic><topic>Calorimetry</topic><topic>Clavicle</topic><topic>Cold Temperature</topic><topic>Computed tomography</topic><topic>Cross-Over Studies</topic><topic>Deoxyglucose</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Down-Regulation - drug effects</topic><topic>Energy</topic><topic>Energy metabolism</topic><topic>Energy Metabolism - drug effects</topic><topic>Female</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - pharmacology</topic><topic>Humans</topic><topic>lipid</topic><topic>Lipogenesis</topic><topic>Male</topic><topic>metabolism</topic><topic>Obesity</topic><topic>Placebos</topic><topic>Positron emission tomography</topic><topic>Prednisolone</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - pharmacology</topic><topic>regulation</topic><topic>Skin</topic><topic>Skin Temperature - drug effects</topic><topic>Temperature</topic><topic>Temperature effects</topic><topic>thermogenesis</topic><topic>Thermogenesis - drug effects</topic><topic>Thermography</topic><topic>Tomography</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Thuzar, Moe</creatorcontrib><creatorcontrib>Law, Weikiat Phillip</creatorcontrib><creatorcontrib>Ratnasingam, Jeyakantha</creatorcontrib><creatorcontrib>Jang, Christina</creatorcontrib><creatorcontrib>Dimeski, Goce</creatorcontrib><creatorcontrib>Ho, Ken K. Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thuzar, Moe</au><au>Law, Weikiat Phillip</au><au>Ratnasingam, Jeyakantha</au><au>Jang, Christina</au><au>Dimeski, Goce</au><au>Ho, Ken K. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2018-04</date><risdate>2018</risdate><volume>20</volume><issue>4</issue><spage>840</spage><epage>848</epage><pages>840-848</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract><![CDATA[Aim
To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans.
Materials and methods
In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period. BAT function was assessed in response to cooling (19°C) and to a standardized meal, by measuring fluoro‐deoxyglucose (FDG) uptake using positron emission tomography‐computed tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry.
Results
During cooling, prednisolone significantly reduced BAT FDG uptake (standardized uptake value, SUVmax, 6.1 ± 2.2 vs 3.7 ± 1.2; P < .05) and SCL temperature (−0.45 ± 0.1 vs −1.0 ± 0.1°C; P < .01) compared to placebo. Postprandially, prednisolone significantly blunted the rise in SCL temperature (+0.2 ± 0.1 vs −0.3 ± 0.1°C; P < .05), enhanced energy production (+221 ± 17 vs +283 ± 27 kcal/d; P < .01) and lipid synthesis (+16.3 ± 3.2 vs +23.6 ± 4.9 mg/min; P < .05). The prednisolone‐induced reduction in SCL temperature significantly correlated with the reduction in FDG uptake (r = 0.65, P < .05), while the increase in energy production significantly correlated with the increase in lipogenesis (r = 0.6, P < .05).
Conclusion
Prolonged exposure to glucocorticoid suppresses the function of human BAT. The enhancement of energy production and lipogenesis in the face of reduced dissipation of energy as heat suggests that glucocorticoids channel energy towards fat storage after nutrient intake. This is a novel mechanism of glucocorticoid‐induced obesity.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>29119718</pmid><doi>10.1111/dom.13157</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2508-9588</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals |
| subjects | Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - physiology Adolescent Adult brown adipose tissue brown fat Calorimetry Clavicle Cold Temperature Computed tomography Cross-Over Studies Deoxyglucose Double-Blind Method Double-blind studies Down-Regulation - drug effects Energy Energy metabolism Energy Metabolism - drug effects Female Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Humans lipid Lipogenesis Male metabolism Obesity Placebos Positron emission tomography Prednisolone Prednisolone - administration & dosage Prednisolone - pharmacology regulation Skin Skin Temperature - drug effects Temperature Temperature effects thermogenesis Thermogenesis - drug effects Thermography Tomography Young Adult |
| title | Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study |
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