Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study

Aim To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans. Materials and methods In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period....

Full description

Saved in:
Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2018-04, Vol.20 (4), p.840-848
Main Authors: Thuzar, Moe, Law, Weikiat Phillip, Ratnasingam, Jeyakantha, Jang, Christina, Dimeski, Goce, Ho, Ken K. Y.
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - physiology
Adolescent
Adult
brown adipose tissue
brown fat
Calorimetry
Clavicle
Cold Temperature
Computed tomography
Cross-Over Studies
Deoxyglucose
Double-Blind Method
Double-blind studies
Down-Regulation - drug effects
Energy
Energy metabolism
Energy Metabolism - drug effects
Female
Glucocorticoids
Glucocorticoids - administration & dosage
Glucocorticoids - pharmacology
Humans
lipid
Lipogenesis
Male
metabolism
Obesity
Placebos
Positron emission tomography
Prednisolone
Prednisolone - administration & dosage
Prednisolone - pharmacology
regulation
Skin
Skin Temperature - drug effects
Temperature
Temperature effects
thermogenesis
Thermogenesis - drug effects
Thermography
Tomography
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim To investigate the effect of glucocorticoids on brown adipose tissue (BAT) function in humans. Materials and methods In a randomized double‐blind cross‐over design, 13 healthy adults underwent 1 week of oral prednisolone treatment (15 mg/d) and placebo with an intervening 2‐week wash‐out period. BAT function was assessed in response to cooling (19°C) and to a standardized meal, by measuring fluoro‐deoxyglucose (FDG) uptake using positron emission tomography‐computed tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry. Results During cooling, prednisolone significantly reduced BAT FDG uptake (standardized uptake value, SUVmax, 6.1 ± 2.2 vs 3.7 ± 1.2; P 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.13157