Functional Anti-Phospholipid Antibodies are Elevated in Chronic Rhinosinusitis with Nasal Polyp Tissue

Rationale Nasal polyps (NP) in Chronic Rhinosinusitis with NP (CRSwNP) contain increased fibrin deposition and auto-antibodies, similar to what is found in the antiphospholipid syndrome, where antiphospholipid antibodies (APA) cause prolongation of the activated partial thrombin time (aPTT) in vitro...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB204-AB204
Main Authors: Tan, Bruce K., Wu, Jeffanie, Stevens, Whitney W., Lindholm, Paul F., Huang, Julia He, Hulse, Kathryn E., Kato, Atsushi, Conley, David B., Welch, Kevin C., Kern, Robert C., Peters, Anju T., Grammer, Leslie C., Schleimer, Robert P.
Format: Article
Language:English
Subjects:
Antiphospholipid antibodies
Immunoglobulins
Phospholipids
Proteins
Rhinitis
Rhinosinusitis
Sinusitis
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Summary:Rationale Nasal polyps (NP) in Chronic Rhinosinusitis with NP (CRSwNP) contain increased fibrin deposition and auto-antibodies, similar to what is found in the antiphospholipid syndrome, where antiphospholipid antibodies (APA) cause prolongation of the activated partial thrombin time (aPTT) in vitro but hypercoagulability in vivo. Results Anti-cardiolipin IgG was significantly increased (p=0.0002) in NP (449.3 GPLU/mg protein) compared to ET from control (89.9 GPLU/mg protein), CRSsNP (187.9 GPLU/mg protein), and CRSwNP (207.4 GPLU/mg protein), and was strongly correlated with anti-dsDNA IgG levels (r=0.75, p
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.646