Photocontrolled Release of Chemicals from Nano‐ and Microparticle Containers

A benzoin‐derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker unit was performed to enable the defined encapsulation of diverse organic compounds in the polymeric...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-02, Vol.57 (9), p.2479-2482
Main Authors: Englert, Christoph, Nischang, Ivo, Bader, Cornelia, Borchers, Philipp, Alex, Julien, Pröhl, Michael, Hentschel, Martin, Hartlieb, Matthias, Traeger, Anja, Pohnert, Georg, Schubert, Stephanie, Gottschaldt, Michael, Schubert, Ulrich S.
Format: Article
Language:English
Subjects:
Benzoin
Biocompatibility
Confocal microscopy
Containers
Degradation products
Drugs
Encapsulation
Hydrophobicity
Irradiation
Kinetics
Lasers
Microscopy
microstructures
nanostructures
Optimization
Organic compounds
Packaging
photochemistry
Physicochemical properties
Polyester resins
Polyesters
Scanning microscopy
Ultraviolet radiation
UV light
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Summary:A benzoin‐derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker unit was performed to enable the defined encapsulation of diverse organic compounds in the polymeric structures and allow for a well‐controllable polymer cleavage process. Selective tracking of the release kinetics of encapsulated model compounds from the polymeric nano‐ and microparticle containers was performed by confocal laser scanning microscopy in a proof‐of‐principle study. The physicochemical properties of the incorporated and released model compounds ranged from fully hydrophilic to fully hydrophobic. The demonstrated biocompatibility of the utilized polyesters and degradation products enables their use in advanced applications, for example, for the smart packaging of UV‐sensitive pharmaceuticals, nutritional components, or even in the area of spatially selective self‐healing processes. Chemicals on demand: Biocompatible polyesters were synthesized that can be fully decomposed by UV irradiation. The formation of nano‐ and microparticles allows for the defined encapsulation of structurally diverse organic compounds and a controllable cleavage process. These particles can be used for the smart packaging of UV‐sensitive pharmaceuticals or for spatially selective self‐healing processes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201710756